Simon C. Watkins

The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock.

Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature.

Induction of anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) and CD4(+) T-cell reactivity by dendritic cells loaded with HIV-1 X4-infected apoptotic cells.

Role of glutathione conjugate efflux in cellular protection against benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage.

Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility.

Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide.

Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair.

Nerve growth factor-induced differentiation changes the cellular organization of regulated Peptide release by PC12 cells.

Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate.

Peroxisomal localization of inducible nitric oxide synthase in hepatocytes.

Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite.

Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells.

Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli.

Depletion of pulmonary EC-SOD after exposure to hyperoxia.

Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor.

Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production.

Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice.

CYR61 (CCN1) is essential for placental development and vascular integrity.

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery.

Chronic exposure to interleukin 1beta induces a delayed and reversible alteration in excitation-contraction coupling of cultured cardiomyocytes.

Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper.

Vascularization and tissue infiltration of a biodegradable polyurethane matrix.

Identification of c-kit-positive cells in the mouse ureter: the interstitial cells of Cajal of the urinary tract.

Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes.

Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury.

Expression and localization of human lysozyme in the endosperm of transgenic rice.

Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis.

Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock.

A role for class A scavenger receptor in dendritic cell nibbling from live cells.

Cellular mechanisms of interleukin-12-mediated neuroblastoma regression.

Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress.

Localization of the BiP molecular chaperone with respect to endoplasmic reticulum foci containing the cystic fibrosis transmembrane conductance regulator in yeast.

Tumor-localization by adoptively transferred, interleukin-2-activated NK cells leads to destruction of well-established lung metastases.

Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia.

Caspase-8 expression and proteolysis in human brain after severe head injury.

Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway.

Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage.

Directional motility induced by epidermal growth factor requires Cdc42.

Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation.

Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects.

Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice.

Multimodal optical imaging.

Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium.

Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export.

Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells through terminal differentiation.

Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity.

Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein.

Some morphological, growth, and genomic properties of human cells chronically infected with porcine endogenous retrovirus (PERV).

Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model.

Rapid and extensive membrane reorganization by dendritic cells following exposure to bacteria revealed by high-resolution imaging.

Vesicular stomatitis virus expressing a chimeric Sindbis glycoprotein containing an Fc antibody binding domain targets to Her2/neu overexpressing breast cancer cells.

Adenovirus-transduced dendritic cells injected into skin or lymph node prime potent simian immunodeficiency virus-specific T cell immunity in monkeys.

Differential effects of actin cytoskeleton dynamics on equine infectious anemia virus particle production.

Cdk-inhibitors and exit from quiescence in primitive haematopoietic cell subsets.

Endocytic adaptor molecules reveal an endosomal population of clathrin by total internal reflection fluorescence microscopy.

Escherichia coli expressing recombinant antigen and listeriolysin O stimulate class I-restricted CD8+ T cells following uptake by human APC.

Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1.

Resolution of anaphase bridges in cancer cells.

Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway.

Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency.

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.

Redistribution of pulmonary EC-SOD after exposure to asbestos.

Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells.

Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines.

Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling.

Beta-synemin localizes to regions of high stress in human skeletal myofibers.

Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells.

Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts.

Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease.

Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans.

Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53.

Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin.

Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases.

Dynamics of dendritic cell phenotype and interactions with CD4+ T cells in airway inflammation and tolerance.

Physical and functional association of migfilin with cell-cell adhesions.

Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma.

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

The characterization of tumor apoptosis after experimental radiosurgery.

Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy.

Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes.

Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors.

Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis.

Gene transfer to human joints: progress toward a gene therapy of arthritis.

Guidance of engineered tissue collagen orientation by large-scale scaffold microstructures.

Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways.

Functional connectivity between immune cells mediated by tunneling nanotubules.

IL-18-induced CD83+CCR7+ NK helper cells.

Nitric oxide and zinc homeostasis in acute lung injury.

Improvement of human lysozyme expression in transgenic rice grain by combining wheat (Triticum aestivum) puroindoline b and rice (Oryza sativa) Gt1 promoters and signal peptides.

Tumor cell loaded type-1 polarized dendritic cells induce Th1-mediated tumor immunity.

Fluorescence resonance energy transfer-based assays for the real-time detection of nitric oxide signaling.

Regulation of Sar1 NH2 terminus by GTP binding and hydrolysis promotes membrane deformation to control COPII vesicle fission.

DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages.

Mini-dystrophin efficiently incorporates into the dystrophin protein complex in living cells.

Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein.

The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.

Gene expression profiling of target genes in ventilator-induced lung injury.

Combinational FLt3 ligand and granulocyte macrophage colony-stimulating factor treatment promotes enhanced tumor infiltration by dendritic cells and antitumor CD8(+) T-cell cross-priming but is ineffective as a therapy.

boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats.

Polysomes are associated with microtubules in fertilized eggs of Chinese pine (Pinus tabulaeformis).

Mycoplasma fermentans and TNF-beta interact to amplify immune-modulating cytokines in human lung fibroblasts.

Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells.

Alpha-sarcoglycan is recycled from the plasma membrane in the absence of sarcoglycan complex assembly.

Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation.

DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes.

A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors.

Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: role of p38 MAPK.

Rapid adaptation of a recombinant vesicular stomatitis virus to a targeted cell line.

Comprehensive analysis of gene expression on GOLD-2 Versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD.

Intravital fluorescence microscopy in pulmonary research.

Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death.

Cell-surface protein disulfide isomerase is required for transnitrosation of metallothionein by S-nitroso-albumin in intact rat pulmonary vascular endothelial cells.

The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane.

Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death.

Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export.

Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans.

Phagocytosis induces lysosome remodeling and regulated presentation of particulate antigens by activated dendritic cells.

The Hsp40 molecular chaperone Ydj1p, along with the protein kinase C pathway, affects cell-wall integrity in the yeast Saccharomyces cerevisiae.

Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells.

Dynamic properties of antigen uptake and communication between dendritic cells.

Treatment-enhanced CD4+Foxp3+ glucocorticoid-induced TNF receptor family related high regulatory tumor-infiltrating T cells limit the effectiveness of cytokine-based immunotherapy.

Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: exacerbation by caspase and serine protease inhibition.

Golgi-associated maturation of very low density lipoproteins involves conformational changes in apolipoprotein B, but is not dependent on apolipoprotein E.

Association of gag multimers with filamentous actin during equine infectious anemia virus assembly.

Generation of FGF reporter transgenic zebrafish and their utility in chemical screens.

Distinct intracellular trafficking of equine infectious anemia virus and human immunodeficiency virus type 1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays.

Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester.

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.

Potential solutions for confocal imaging of living animals.

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness.

Virologic and immunologic events in hilar lymph nodes during simian immunodeficiency virus infection: development of polarized inflammation.

Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury.

Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice.

GTP-dependent polymerization of the tubulin-like RepX replication protein encoded by the pXO1 plasmid of Bacillus anthracis.

Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus.

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury.

Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes.

Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition.

Memory CD8+ T cells protect dendritic cells from CTL killing.

Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis.

Spatiotemporal response of living cell structures in Dictyostelium discoideum with semiconductor quantum dots.

Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection.

Nitric-oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone.

CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema.

p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid.

CD8+ T-cell responses against hemoglobin-beta prevent solid tumor growth.

Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.

The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.

Starving neurons show sex difference in autophagy.

Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses.

Effective immunotherapy against murine gliomas using type 1 polarizing dendritic cells--significant roles of CXCL10.

Noncytotoxic suppression of human immunodeficiency virus type 1 transcription by exosomes secreted from CD8+ T cells.

The tubulin-like RepX protein encoded by the pXO1 plasmid forms polymers in vivo in Bacillus anthracis.

AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells.

Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner.

Using total internal reflection fluorescence (TIRF) microscopy to visualize cortical actin and microtubules in the Drosophila syncytial embryo.

Dendritic cell altered states: what role for calcium?

WITHDRAWN: Communication between immune cells mediated by membrane connections.

HIV-1 infection of DC: evidence for the acquisition of virus particles from infected T cells by antigen uptake mechanism.

IL-6 adsorption dynamics in hemoadsorption beads studied using confocal laser scanning microscopy.

Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.

Ectopic T-bet expression licenses dendritic cells for IL-12-independent priming of type 1 T cells in vitro.

DC expressing transgene Foxp3 are regulatory APC.

Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development.

Confocal microscopy: comparisons, applications, and problems.

Characterization of an lhx1a transgenic reporter in zebrafish.

Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.

Inhibition and role of let-7d in idiopathic pulmonary fibrosis.

Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.

Stratification of Antigen-presenting Cells within the Normal Cornea.

Sar1 assembly regulates membrane constriction and ER export.

Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice.

The second extracellular loop dictates Occludin-mediated HCV entry.

Accelerated aging of intervertebral discs in a mouse model of progeria.

Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination.

Intratumoral IL-12 gene therapy results in the crosspriming of Tc1 cells reactive against tumor-associated stromal antigens.

An unexpected role for the clock protein timeless in developmental apoptosis.

A role for zinc in regulating hypoxia-induced contractile events in pulmonary endothelium.

Extracellular superoxide dismutase in macrophages augments bacterial killing by promoting phagocytosis.

Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane.

Complement proteins C3 and C4 bind to collagen and elastin in the vascular wall: a potential role in vascular stiffness and atherosclerosis.

Are mitochondrial reactive oxygen species required for autophagy?

Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains.

Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG4.

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

Direct visualization of HIV-1 with correlative live-cell microscopy and cryo-electron tomography.

The engineering of organized human corneal tissue through the spatial guidance of corneal stromal stem cells.

Allele Specific Transactivation of Matrix Metalloproteinase 7 by FOXA2 and Correlation with Plasma Levels in Idiopathic Pulmonary Fibrosis.

p53/HMGB1 complexes regulate autophagy and apoptosis.

Pharmacological rescue of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) detected by use of a novel fluorescence platform.

The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.

Genetically encoded pH sensor for tracking surface proteins through endocytosis.

Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.

Obesity-induced tissue free radical generation: an in vivo immuno-spin trapping study.

NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Quantitative Proteomics Reveal ATM Kinase-dependent Exchange in DNA Damage Response Complexes.

High resolution imaging of vascular function in zebrafish.

Dynamin- and Rab5-Dependent Endocytosis of a Ca(2+)-Activated K(+) Channel, KCa2.3.

Mitochondrial hyperfusion induced by loss of fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress.

Hydrogels derived from central nervous system extracellular matrix.

GENE EXPRESSION AND COLLAGEN FIBER MICROMECHANICAL INTERACTIONS OF THE SEMILUNAR HEART VALVE INTERSTITIAL CELL.

Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro.

Regional structural and biomechanical alterations of the ovine main pulmonary artery during postnatal growth.

PEX7 and EBP50 target iNOS to the peroxisome in hepatocytes.

Regulated recycling of mutant CFTR is partially restored by pharmacological treatment.

Interaction Between Her2 and Beclin-1 Underlies a New Mechanism of Reciprocal Regulation.

Mechanism of aortic medial matrix remodeling is distinct in patients with bicuspid aortic valve.