Unit Lyssavirus Epidemiology and Neuropathology,
National Reference Center for Rabies and WHO Collaborating Center for Reference and Research on Rabies,
Unit Lyssavirus Epidemiology and Neuropathology, National Reference Center for Rabies and WHO Collaborating Center for Reference and Research on Rabies
Laurent Dacheux received his doctorate in Pharmaceutical Sciences (PharmD) in 2000 from the University of Sciences and Techniques of Tours, France, after defending his thesis on anticancer immunotherapy and pharmacogenetics. He was then graduated in 2005 from a Doctorate in Science (PhD) also at the University of Sciences and Techniques of Tours, France, still in the field of monoclonal antibodies but applied to infectious diseases, and more specifically to HIV.
Since 2004, Laurent Dacheux is acting as one of the deputy directors of the National Reference Center for Rabies (NRC-R) at Institut Pasteur, Paris. Among the several missions dedicated to this center and provided by the French Ministry of Health, he is more specifically invested in the development, the validation and the diffusion of the diagnostic techniques related to rabies. One of his topics in this field is focused on the improvement of the diagnosis of human and animal rabies in the endemic areas through the development of innovative, rapid and applicable tests in field conditions.
In parallel, Laurent Dacheux is also involved in the WHO Collaborative Centre for Research and Reference on Rabies (WHO-CC Rabies), in which he is in charge of various activities focused on the diagnosis, especially those regarding training activities through lectures and organization of workshops in Asia and Africa.
Lastly, he is also a permanent research engineer in the Lyssavirus, Epidemiology and Neuropathology unit (which housed both the NRC-R and the WHO-CC Rabies). In this unit, he is leading integrated researches focused on the two main animal reservoirs of rabies, with carnivores (mainly dogs) and bats, in an One Health approach.
Genomic diversity and evolution of the lyssaviruses.
PloS one Apr, 2008 | Pubmed ID: 18446239
Phi29 polymerase based random amplification of viral RNA as an alternative to random RT-PCR.
BMC molecular biology Sep, 2008 | Pubmed ID: 18771595
The origin and phylogeography of dog rabies virus.
The Journal of general virology Nov, 2008 | Pubmed ID: 18931062
European bat Lyssavirus transmission among cats, Europe.
Emerging infectious diseases Feb, 2009 | Pubmed ID: 19193273
Imported episodic rabies increases patient demand for and physician delivery of antirabies prophylaxis.
PLoS neglected tropical diseases Jun, 2010 | Pubmed ID: 20582307
Application of broad-spectrum resequencing microarray for genotyping rhabdoviruses.
Journal of virology Sep, 2010 | Pubmed ID: 20610710
[The use of passive rabies immunotherapy: from the past to the future].
Biologie aujourd'hui , 2010 | Pubmed ID: 20950578
More accurate insight into the incidence of human rabies in developing countries through validated laboratory techniques.
PLoS neglected tropical diseases Nov, 2010 | Pubmed ID: 21152054
Massively parallel pathogen identification using high-density microarrays.
Microbial biotechnology Jan, 2008 | Pubmed ID: 21261824
Lyssavirus detection and typing using pyrosequencing.
Journal of clinical microbiology May, 2011 | Pubmed ID: 21389152
Human rabies encephalitis prevention and treatment: progress since Pasteur's discovery.
Infectious disorders drug targets Jun, 2011 | Pubmed ID: 21488832
Evaluation of high-throughput sequencing for identifying known and unknown viruses in biological samples.
Journal of clinical microbiology Sep, 2011 | Pubmed ID: 21715589
First human rabies case in French Guiana, 2008: epidemiological investigation and control.
PLoS neglected tropical diseases , 2012 | Pubmed ID: 22363830
[Rabies].
Medecine sciences : M/S Jan, 2013 | Pubmed ID: 23351694
Surveillance and control of rabies in La Reunion, Mayotte, and Madagascar.
Veterinary research Sep, 2013 | Pubmed ID: 24016204
Recent emergence and spread of an Arctic-related phylogenetic lineage of rabies virus in Nepal.
PLoS neglected tropical diseases Nov, 2013 | Pubmed ID: 24278494
A preliminary study of viral metagenomics of French bat species in contact with humans: identification of new mammalian viruses.
PloS one , 2014 | Pubmed ID: 24489870
Rabies in nonhuman primates and potential for transmission to humans: a literature review and examination of selected French national data.
PLoS neglected tropical diseases May, 2014 | Pubmed ID: 24831694
Severe ketoalkalosis as initial presentation of imported human rabies in France.
Journal of clinical microbiology Jun, 2015 | Pubmed ID: 25854482
Genetic Diversity within Alphaherpesviruses: Characterization of a Novel Variant of Herpes Simplex Virus 2.
Journal of virology Dec, 2015 | Pubmed ID: 26401046
Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community.
PLoS neglected tropical diseases Jan, 2016 | Pubmed ID: 26808820
The potential lethal consequences of rabies vaccine avoidance and dog smuggling in Europe.
The Journal of infection May, 2016 | Pubmed ID: 26940506
Dual Combined Real-Time Reverse Transcription Polymerase Chain Reaction Assay for the Diagnosis of Lyssavirus Infection.
PLoS neglected tropical diseases 07, 2016 | Pubmed ID: 27380028
Validation of a Rapid Rabies Diagnostic Tool for Field Surveillance in Developing Countries.
PLoS neglected tropical diseases Oct, 2016 | Pubmed ID: 27706156
Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts.
PLoS pathogens Dec, 2016 | Pubmed ID: 27977811
Development and validation of sensitive real-time RT-PCR assay for broad detection of rabies virus.
Journal of virological methods 05, 2017 | Pubmed ID: 28174073
The Recently Discovered Bokeloh Bat Lyssavirus: Insights Into Its Genetic Heterogeneity and Spatial Distribution in Europe and the Population Genetics of Its Primary Host.
Advances in virus research , 2017 | Pubmed ID: 29029727
Host Genetic Variation Does Not Determine Spatio-Temporal Patterns of European Bat 1 Lyssavirus.
Genome biology and evolution 11, 2017 | Pubmed ID: 29165566
Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure.
Science translational medicine Dec, 2017 | Pubmed ID: 29263230
The shift in rabies epidemiology in France: time to adjust rabies post-exposure risk assessment.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 09, 2018 | Pubmed ID: 30280687
Comparison of intra- and inter-host genetic diversity in rabies virus during experimental cross-species transmission.
PLoS pathogens 06, 2019 | Pubmed ID: 31220188
Co-circulation and characterization of novel African arboviruses (genus Ephemerovirus) in cattle, Mayotte island, Indian Ocean, 2017.
Transboundary and emerging diseases Nov, 2019 | Pubmed ID: 31390479
[Rabies].
La Revue du praticien Apr, 2019 | Pubmed ID: 31626500
Enabling animal rabies diagnostic in low-access areas: Sensitivity and specificity of a molecular diagnostic test from cerebral tissue dried on filter paper.
PLoS neglected tropical diseases 03, 2020 | Pubmed ID: 32142519
Epidemiology of rabies cases among international travellers, 2013-2019: A retrospective analysis of published reports.
Travel medicine and infectious disease Jun, 2020 | Pubmed ID: 32525075
Revisiting the Classification of Percid Perhabdoviruses Using New Full-Length Genomes.
Viruses Jun, 2020 | Pubmed ID: 32560066
Immune response to rabies post-exposure prophylaxis in patients with non-HIV secondary immunodeficiencies.
Vaccine Jun, 2020 | Pubmed ID: 32586759
Charles E. Rupprecht1,
Wei-Cheng Hsu2,
Feng Ye3,
Megan Golding4,
Luca Zaeck5,
Laurent Dacheux6,
Noel Tordo7,
Jodie A. Jarvis8,
Erin Patrick9,
Are Berentsen10
1, LYSSA LLC,
2Animal Health Research Institute, Council of Agriculture, Executive Yuan,
3Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences,
4Wildlife Zoonoses & Vector-Borne Diseases Research Group, Animal and Plant Health Agency,
5Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health,
6Unit Lyssavirus Epidemiology and Neuropathology, National Reference Center for Rabies and WHO Collaborating Center for Reference and Research on Rabies, Institut Pasteur,
7Unit Antiviral Strategies, OIE Reference Laboratories for Rift Valley Fever Virus & Crimean Congo Hemorrhagic Fever Virus, Institut Pasteur, Institut Pasteur de Guinea, Conakry,
8Rabies Laboratory, Wadsworth Center, New York State Department of Health,
9Animal and Plant Health Inspection Service, Wildlife Services, Knoxville, TN, US Department of Agriculture,
10Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, US Department of Agriculture
Stephanie Mauti1,
Monique Léchenne2,
Service Naïssengar3,
Abdallah Traoré4,
Vessaly Kallo5,6,
Casimir Kouakou7,
Emmanuel Couacy-Hymann7,
Morgane Gourlaouen8,
Céline Mbilo9,10,
Pati Patient Pyana11,
Enos Madaye3,
Ibrahima Dicko4,
Pascal Cozette1,
Paola De Benedictis8,
Hervé Bourhy1,
Jakob Zinsstag9,10,
Laurent Dacheux1
1Unit Lyssavirus Epidemiology and Neuropathology, National Reference Center for Rabies and WHO Collaborating Center for Reference and Research on Rabies, Institut Pasteur,
2Environment and Sustainability Institute, University of Exeter, Penryn Campus,
3, Institut de Recherche en Elevage pour le Développement,
4, Laboratoire Central Vétérinaire,
5, Direction des Services Vétérinaires,
6, Ecole Inter Etats de Sciences et de Médecine Vétérinaires de Dakar,
7Laboratoire Central Vétérinaire de Bingerville, Laboratoire National d'Appui au Développement Agricole Bingerville,
8FAO Reference Centre for Rabies, Istituto Zooprofilattico Sperimentale delle Venezie,
9, Swiss Tropical and Public Health Institute,
10, University of Basel,
11, Institut National de Recherche Biomédicale
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