Martha R. Stampfer

Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells.

Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion.

Human epithelial cell immortalization as a step in carcinogenesis.

Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines.

Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.

Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter.

Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models.

ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.

Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized.

Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.

Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation.

Cell type-specific DNA methylation patterns in the human breast.

Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.

Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells.

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments.

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A).

Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells.

Epigenetic regulation of normal human mammary cell type-specific miRNAs.

Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia.