Kerstin Krieglstein

TGF-beta and the regulation of neuron survival and death.

Mechanisms of TGF-beta-mediated apoptosis.

TGF-beta is required for programmed cell death in interdigital webs of the developing mouse limb.

The role of transforming growth factor beta-2, beta-3 in mediating apoptosis in the murine intestinal mucosa.

TGF-beta induces cell death in the oligodendroglial cell line OLI-neu.

Transforming growth factor-beta induced cell death in the developing chick retina is mediated via activation of c-jun N-terminal kinase and downregulation of the anti-apoptotic protein Bcl-X(L).

Tgfbeta2 -/- Tgfbeta3 -/- double knockout mice display severe midline fusion defects and early embryonic lethality.

TGF-betas and their roles in the regulation of neuron survival.

Transforming growth factor beta2 is released from PC12 cells via the regulated pathway of secretion.

Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo.

Reduced programmed cell death in the retina and defects in lens and cornea of Tgfbeta2(-/-) Tgfbeta3(-/-) double-deficient mice.

Transforming growth factor-beta and tumor necrosis factor-alpha cooperate to induce apoptosis in the oligodendroglial cell line OLI-neu.

Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins.

TIEG1 facilitates transforming growth factor-beta-mediated apoptosis in the oligodendroglial cell line OLI-neu.

Nerve growth factor mediates activation of the Smad pathway in PC12 cells.

GDNF promotes neuronal differentiation and dopaminergic development of mouse mesencephalic neurospheres.

TGF-beta promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8.

Factors promoting survival of mesencephalic dopaminergic neurons.

Induction and specification of midbrain dopaminergic cells: focus on SHH, FGF8, and TGF-beta.

The dopaminergic nigrostriatal system: development, physiology, disease.

Isoform-specific role of transforming growth factor-beta2 in the regulation of proliferation and differentiation of murine adrenal chromaffin cells in vivo.

Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse.

Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon.

Cell death in the nervous system.

GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action.

Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain.

Specificity in the crosstalk of TGFbeta/GDNF family members is determined by distinct GFR alpha receptors.

Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7.

Transforming growth factor beta cooperates with persephin for dopaminergic phenotype induction.

In vivo requirement of TGF-beta/GDNF cooperativity in mouse development: focus on the neurotrophic hypothesis.

Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.

TGF-beta superfamily members, ActivinA and TGF-beta1, induce apoptosis in oligodendrocytes by different pathways.

Involvement of Fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells.

Differentiation of embryonic stem cells.

Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component.

TGF-beta in dopamine neuron development, maintenance and neuroprotection.

Tieg1/Klf10 is upregulated by NGF and attenuates cell cycle progression in the pheochromocytoma cell line PC12.

TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP.

Aged Tgfbeta2/Gdnf double-heterozygous mice show no morphological and functional alterations in the nigrostriatal system.

Thapsigargin-induced Ca2+ increase inhibits TGFβ1-mediated Smad2 transcriptional responses via Ca2+/calmodulin-dependent protein kinase II.

Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development.

Fibrosis and evidence for epithelial-mesenchymal transition in the kidneys of patients with staghorn calculi.

Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons.

Klf10 and Klf11 as mediators of TGF-beta superfamily signaling.

More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses.

Neuregulin 1 type III/ErbB signaling is crucial for Schwann cell colonization of sympathetic axons.

IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP(+)-Induced Neurodegeneration.

Schwann cells migrate along axons in the absence of GDNF signaling.

TGFβ signalling plays an important role in IL4-induced alternative activation of microglia.

Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro.