Biomedical Engineering Department,
Translational Tissue Engineering Center,
Wilmer Eye Institute,
Institute for Nanobiotechnology,
Biomedical Engineering,
Ophthalmology,
Oncology,
Neurosurgery,
Materials Science and Engineering,
Chemical and Biomolecular Engineering,
and the Bloomberg-Kimmel Institute for Cancer Immunotherapy,
Biomedical Engineering, Translational Tissue Engineering Center, Institute for Nanobiotechnology, Ophthalmology, Oncology, Neurosurgery, Materials Science and Engineering, Chemical and Biomolecular Engineering, and the Bloomberg-Kimmel Institute for Cancer Immunotherapy
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Nanoengineering approaches to the design of artificial antigen-presenting cells.
Nanomedicine (London, England) Jul, 2013 | Pubmed ID: 23837856
Biodegradable polymeric vectors for gene delivery to human endothelial cells.
Bioconjugate chemistry Sep-Oct, 2006 | Pubmed ID: 16984124
Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells.
Nano letters Apr, 2007 | Pubmed ID: 17362046
A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery.
Accounts of chemical research May, 2008 | Pubmed ID: 18507402
Nanoparticles for gene transfer to human embryonic stem cell colonies.
Nano letters Oct, 2008 | Pubmed ID: 18754690
Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.
Cancer biology & therapy Oct, 2008 | Pubmed ID: 19039293
Poly(beta-amino esters): procedures for synthesis and gene delivery.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19085119
Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery.
Nano letters Jun, 2009 | Pubmed ID: 19422265
Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice.
Cancer research Aug, 2009 | Pubmed ID: 19643734
Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 19805054
Tissue-specific gene delivery via nanoparticle coating.
Biomaterials Feb, 2010 | Pubmed ID: 19850333
Degradable polymers for gene delivery.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference , 2009 | Pubmed ID: 19964958
Electrostatic surface modifications to improve gene delivery.
Expert opinion on drug delivery Apr, 2010 | Pubmed ID: 20201712
The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures.
Biomaterials Nov, 2010 | Pubmed ID: 20674001
Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.
Expert opinion on drug delivery Apr, 2011 | Pubmed ID: 21338327
Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.
Biomaterials Aug, 2011 | Pubmed ID: 21536325
Poly(β-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies.
Journal of controlled release : official journal of the Controlled Release Society Sep, 2011 | Pubmed ID: 21699928
Effects of base polymer hydrophobicity and end-group modification on polymeric gene delivery.
Biomacromolecules Oct, 2011 | Pubmed ID: 21888340
A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles.
Small (Weinheim an der Bergstrasse, Germany) Feb, 2012 | Pubmed ID: 22139973
Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells.
International journal of nanomedicine , 2011 | Pubmed ID: 22228998
Gene delivery nanoparticles specific for human microvasculature and macrovasculature.
Nanomedicine : nanotechnology, biology, and medicine Oct, 2012 | Pubmed ID: 22306159
Therapeutic angiogenesis using genetically engineered human endothelial cells.
Journal of controlled release : official journal of the Controlled Release Society Jun, 2012 | Pubmed ID: 22450331
2011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery.
Annals of biomedical engineering Jul, 2012 | Pubmed ID: 22451256
Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo.
PloS one , 2012 | Pubmed ID: 22629417
Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery.
Therapeutic delivery Apr, 2011 | Pubmed ID: 22826857
Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.
Biomaterials Nov, 2012 | Pubmed ID: 22871421
Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties.
Molecular pharmaceutics Nov, 2012 | Pubmed ID: 22970908
Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer.
Advanced healthcare materials Sep, 2012 | Pubmed ID: 23184674
siRNA nanomedicine: the promise of bioreducible materials.
Expert review of medical devices Jan, 2013 | Pubmed ID: 23278217
Poly(beta-aminoester) nanoparticle-delivery of p53 has activity against small cell lung cancer in vitro and in vivo.
Molecular cancer therapeutics Jan, 2013 | Pubmed ID: 23364678
Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, april 10-13, 2013, Boston, Massachusetts : biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(beta-amino ester)s.
Journal of biomedical materials research. Part A Jul, 2013 | Pubmed ID: 23559534
The effect and role of carbon atoms in poly(β-amino ester)s for DNA binding and gene delivery.
Journal of the American Chemical Society May, 2013 | Pubmed ID: 23570657
A bioreducible linear poly(β-amino ester) for siRNA delivery.
Chemical communications (Cambridge, England) Jun, 2013 | Pubmed ID: 23646347
(3-aminopropyl)-4-methylpiperazine end-capped poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based multilayer films for gene delivery.
ACS applied materials & interfaces Jul, 2013 | Pubmed ID: 23755861
Bioengineered nanoparticles for siRNA delivery.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Sep-Oct, 2013 | Pubmed ID: 23821336
Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide.
Biomaterials Oct, 2013 | Pubmed ID: 23849876
Independent vs. Cooperative Binding in Polyethylenimine-DNA and Poly(L-lysine)-DNA Polyplexes.
The journal of physical chemistry. B Aug, 2013 | Pubmed ID: 23941196
Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells.
Biomaterials Jan, 2014 | Pubmed ID: 24099710
Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine.
Annals of biomedical engineering Jul, 2014 | Pubmed ID: 24170072
Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(β-amino ester) polyplexes in human breast cancer cells.
Bioconjugate chemistry Jan, 2014 | Pubmed ID: 24320687
Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells.
International journal of nanomedicine , 2013 | Pubmed ID: 24348039
Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells.
ACS nano Apr, 2014 | Pubmed ID: 24673565
Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo.
ACS nano May, 2014 | Pubmed ID: 24766032
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2014 | Pubmed ID: 24938788
Highlights from the latest articles in nanomedicine.
Nanomedicine (London, England) 05, 2014 | Pubmed ID: 24978461
Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.
Advanced materials (Deerfield Beach, Fla.) Dec, 2009 | Pubmed ID: 25165411
Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA.
Acta biomaterialia Jan, 2015 | Pubmed ID: 25246314
An automated multidimensional thin film stretching device for the generation of anisotropic polymeric micro- and nanoparticles.
Journal of biomedical materials research. Part A Aug, 2015 | Pubmed ID: 25641799
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
ACS nano Feb, 2015 | Pubmed ID: 25643235
Shaping the future of nanomedicine: anisotropy in polymeric nanoparticle design.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Mar-Apr, 2016 | Pubmed ID: 25981390
Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells.
Stem cells (Dayton, Ohio) Sep, 2015 | Pubmed ID: 26013357
Targeted polymeric nanoparticles for cancer gene therapy.
Journal of drug targeting , 2015 | Pubmed ID: 26061296
Gene delivery polymer structure-function relationships elucidated via principal component analysis.
Chemical communications (Cambridge, England) Aug, 2015 | Pubmed ID: 26126593
Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2015 | Pubmed ID: 26433125
Bioreducible Poly(Beta-Amino Ester)s for Intracellular Delivery of SiRNA.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 26472444
Layer-by-layer inorganic/polymeric nanoparticles for kinetically controlled multigene delivery.
Journal of biomedical materials research. Part A 03, 2016 | Pubmed ID: 26519869
Biodegradable polymer iron oxide nanocomposites: the future of biocompatible magnetism.
Nanomedicine (London, England) , 2015 | Pubmed ID: 26608843
Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain.
Biomaterials Apr, 2016 | Pubmed ID: 26828681
Quantification of cellular and nuclear uptake rates of polymeric gene delivery nanoparticles and DNA plasmids via flow cytometry.
Acta biomaterialia 06, 2016 | Pubmed ID: 27019146
Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours.
Ecancermedicalscience , 2016 | Pubmed ID: 27110286
Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.
Biomaterials 09, 2016 | Pubmed ID: 27240162
Non-viral nucleic acid containing nanoparticles as cancer therapeutics.
Expert opinion on drug delivery Oct, 2016 | Pubmed ID: 27248202
Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy.
Acta biomaterialia 09, 2016 | Pubmed ID: 27262740
Gene delivery nanoparticles to modulate angiogenesis.
Advanced drug delivery reviews Sep, 2017 | Pubmed ID: 27913120
Mimicking biological functionality with polymers for biomedical applications.
Nature 12, 2016 | Pubmed ID: 27974772
Noninvasive Targeted Transcranial Neuromodulation via Focused Ultrasound Gated Drug Release from Nanoemulsions.
Nano letters 02, 2017 | Pubmed ID: 28094959
Tyrosine kinase blocking collagen IV-derived peptide suppresses ocular neovascularization and vascular leakage.
Science translational medicine 01, 2017 | Pubmed ID: 28100839
Continuous microfluidic assembly of biodegradable poly(beta-amino ester)/DNA nanoparticles for enhanced gene delivery.
Journal of biomedical materials research. Part A 06, 2017 | Pubmed ID: 28177587
Nanoparticle Tracking Analysis for Determination of Hydrodynamic Diameter, Concentration, and Zeta-Potential of Polyplex Nanoparticles.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28238128
Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing.
Bioengineering & translational medicine Jun, 2016 | Pubmed ID: 28349127
Polymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma.
Journal of controlled release : official journal of the Controlled Release Society Oct, 2017 | Pubmed ID: 28351668
A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 07, 2017 | Pubmed ID: 28479046
Surface engineering for lymphocyte programming.
Advanced drug delivery reviews May, 2017 | Pubmed ID: 28501510
Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy.
Nanomedicine : nanotechnology, biology, and medicine 02, 2018 | Pubmed ID: 29127039
Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma.
Oncotarget Nov, 2017 | Pubmed ID: 29254183
Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells.
Journal of biomedical materials research. Part A Jun, 2018 | Pubmed ID: 29424479
Nanoscale artificial antigen presenting cells for cancer immunotherapy.
Molecular immunology Jun, 2018 | Pubmed ID: 29525074
Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments.
Annual review of chemical and biomolecular engineering Jun, 2018 | Pubmed ID: 29579402
Anisotropic biodegradable lipid coated particles for spatially dynamic protein presentation.
Acta biomaterialia May, 2018 | Pubmed ID: 29631048
Injectable drug depot engineered to release multiple ophthalmic therapeutic agents with precise time profiles for postoperative treatment following ocular surgery.
Acta biomaterialia Jun, 2018 | Pubmed ID: 29684622
Bacterial tRNase-Based Gene Therapy with Poly(β-Amino Ester) Nanoparticles for Suppressing Melanoma Tumor Growth and Relapse.
Advanced healthcare materials Aug, 2018 | Pubmed ID: 29888531
Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival.
Nano letters Jul, 2018 | Pubmed ID: 29927251
Non-Viral Delivery To Enable Genome Editing.
Trends in biotechnology Sep, 2018 | Pubmed ID: 30278987
1Biomedical Engineering Department, Johns Hopkins University School of Medicine,
2Translational Tissue Engineering Center, Johns Hopkins University School of Medicine,
3Wilmer Eye Institute, Johns Hopkins University School of Medicine,
4Institute for Nanobiotechnology, Johns Hopkins University School of Medicine
1Biomedical Engineering, Translational Tissue Engineering Center, Institute for Nanobiotechnology, Johns Hopkins University School of Medicine,
2Biomedical Engineering, Translational Tissue Engineering Center, Institute for Nanobiotechnology, Ophthalmology, Oncology, Neurosurgery, Materials Science and Engineering, Chemical and Biomolecular Engineering, and the Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine
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