ISOF - Bio Free Radicals
Chryssostomos Chatgilialoglu is Research Director at the Italian National Research Council (CNR) in Bologna. He is also Co-Founder and President of the company Lipinutragen. He received the doctorate degree in Industrial Chemistry from Bologna University in 1976 and completed his postdoctoral studies at York University (UK) and the National Research Council of Canada, Ottawa. In 1983, he joined the CNR in Bologna (Italy) where he has been Research Director since 1991. In March 2014 he was appointed as the Director of the Institute of Nanoscience and Nanotechnology at the NCSR “Demokritos” in Athens (Greece) and from May 2015 he served as the vice-President of the NCSR “Demokritos”. In June 2016 he moved back to Bologna, to his Research Director position at the ISOF–CNR. He is the author or co-author of more than 270 publications in peer-reviewed journals, 34 book chapters, 7 patents, and 8 books.
Chairman of the COST Actions Free Radicals in Chemical Biology (2007–2011) and Biomimetic Radical Chemistry (2013–2016). Author and editor of several books, including Organosilanes in Radical Chemistry, Wiley 2004; Encyclopedia of Radicals in Chemistry, Biology and Materials, Wiley 2012; Membrane Lipidomics for Personalized Health, Wiley 2015.
The Chatgilialoglu’s research group is active in the field of free radical chemistry addressed to applications in life sciences. In the recent years, he developed biomimetic chemistry of radical stress and related biomarkers. The discovery of endogenous formation of trans-lipids, research on cyclopurine DNA lesions and fatty acid-based lipidomics attracted worldwide attention. He is responsible for introducing tris(trimethylsilyl)silane (TTMSS) as radical-based reducing agent and for this he was the winner of the Fluka Prize “Reagent of the Year 1990”.
Addition Reactions of Tris(trimethylsilyl)germyl Radicals to Unsaturated Compounds. An EPR and Product Study.
The Journal of organic chemistry Nov, 1997 | Pubmed ID: 11671904
Chemistry of Acyl Radicals.
Chemical reviews Aug, 1999 | Pubmed ID: 11849018
5-Endo-trig radical cyclizations: disfavored or favored processes?
Journal of the American Chemical Society Sep, 2002 | Pubmed ID: 12207532
The kinetics of thiyl radical-induced reactions of monounsaturated fatty acid esters.
Journal of the American Chemical Society Oct, 2002 | Pubmed ID: 12392428
Arachidonate geometrical isomers generated by thiyl radicals: the relationship with trans lipids detected in biological samples.
Free radical biology & medicine Dec, 2002 | Pubmed ID: 12446209
Geometrical isomerism of monounsaturated fatty acids: thiyl radical catalysis and influence of antioxidant vitamins.
Free radical biology & medicine Dec, 2002 | Pubmed ID: 12488136
Model studies of DNA C5' radicals. Selective generation and reactivity of 2'-deoxyadenosin-5'-yl radical.
Journal of the American Chemical Society Apr, 2003 | Pubmed ID: 12656617
Rate constants for the beta-elimination of tosyl radical from a variety of substituted carbon-centered radicals.
The Journal of organic chemistry May, 2003 | Pubmed ID: 12713356
Regioselective cis-trans isomerization of arachidonic double bonds by thiyl radicals: the influence of phospholipid supramolecular organization.
Journal of the American Chemical Society Feb, 2004 | Pubmed ID: 14746474
Selective generation and reactivity of 5'-adenosinyl and 2'-adenosinyl radicals.
Chemistry (Weinheim an der Bergstrasse, Germany) Mar, 2004 | Pubmed ID: 15007814
Excess electron transfer in G-quadruplex.
Chemical communications (Cambridge, England) Aug, 2004 | Pubmed ID: 15278171
A biomimetic model of tandem radical damage involving sulfur-containing proteins and unsaturated lipids.
Chembiochem : a European journal of chemical biology Dec, 2004 | Pubmed ID: 15532103
The photochemistry of 8-bromo-2'-deoxyadenosine. A direct entry to cyclopurine lesions.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology Nov-Dec, 2004 | Pubmed ID: 15570393
Synthesis and biological evaluation of novel 1'-branched and spironucleoside analogues.
Nucleosides, nucleotides & nucleic acids , 2004 | Pubmed ID: 15620096
The kinetics of Z/E isomerization of methyl oleate catalyzed by photogenerated thiyl radicals.
Chemphyschem : a European journal of chemical physics and physical chemistry Feb, 2005 | Pubmed ID: 15751351
Trans lipid formation induced by thiols in human monocytic leukemia cells.
Free radical biology & medicine May, 2005 | Pubmed ID: 15808415
Synthesis of all-trans arachidonic acid and its effect on rabbit platelet aggregation.
Bioorganic & medicinal chemistry letters Jun, 2005 | Pubmed ID: 15876534
The influence of solid-state molecular organization on the reaction paths of thiyl radicals.
Chemphyschem : a European journal of chemical physics and physical chemistry Jun, 2005 | Pubmed ID: 15883998
Trans lipids: the free radical path.
Accounts of chemical research Jun, 2005 | Pubmed ID: 15966710
Tautomers of one-electron-oxidized guanosine.
Angewandte Chemie (International ed. in English) Sep, 2005 | Pubmed ID: 16106467
Comparison of phosphatidylcholine vesicle properties related to geometrical isomerism.
Photochemistry and photobiology Jan-Feb, 2006 | Pubmed ID: 16117569
Geometrical trans lipid isomers: a new target for lipidomics.
Chembiochem : a European journal of chemical biology Oct, 2005 | Pubmed ID: 16196019
Trans fatty acids and atopic eczema/dermatitis syndrome: the relationship with a free radical cis-trans isomerization of membrane lipids.
Lipids Jul, 2005 | Pubmed ID: 16196416
Complex sequence dependence by excess-electron transfer through DNA with different strength electron acceptors.
Angewandte Chemie (International ed. in English) Dec, 2005 | Pubmed ID: 16315329
Probing the influence of cis-trans isomers on model lipid membrane fluidity using cis-parinaric acid and a stop-flow technique.
Chemical communications (Cambridge, England) Feb, 2006 | Pubmed ID: 16432572
Reductive modification of a methionine residue in the amyloid-beta peptide.
Angewandte Chemie (International ed. in English) Apr, 2006 | Pubmed ID: 16538691
Occurrence of trans fatty acids in rats fed a trans-free diet: a free radical-mediated formation?
Free radical biology & medicine May, 2006 | Pubmed ID: 16632115
C5'-adenosinyl radical cyclization. A stereochemical investigation.
The Journal of organic chemistry Jun, 2006 | Pubmed ID: 16749773
Trans-fatty acids and radical stress: what are the real culprits?
Bioorganic & medicinal chemistry Sep, 2006 | Pubmed ID: 16766191
Chemical radiation studies of 8-bromo-2'-deoxyinosine and 8-bromoinosine in aqueous solutions.
Chemistry (Weinheim an der Bergstrasse, Germany) Oct, 2006 | Pubmed ID: 16823787
The reaction of hydrogen atoms with methionine residues: A model of reductive radical stress causing tandem protein-lipid damage.
Chembiochem : a European journal of chemical biology Nov, 2006 | Pubmed ID: 16977666
Tautomerism in the guanyl radical.
Journal of the American Chemical Society Oct, 2006 | Pubmed ID: 17044708
Reactions of hydrogen atoms with met-enkephalin and related peptides.
Chemistry (Weinheim an der Bergstrasse, Germany) , 2007 | Pubmed ID: 17124712
Independent generation of C5'-nucleosidyl radicals in thymidine and 2'-deoxyguanosine.
The Journal of organic chemistry May, 2007 | Pubmed ID: 17425368
The sulfhydryl radical (HS(.)/S(.-)): a contender for the isomerization of double bonds in membrane lipids.
Angewandte Chemie (International ed. in English) , 2007 | Pubmed ID: 17450618
Lipid metabolism and diet: possible mechanisms of slow aging.
The international journal of biochemistry & cell biology , 2008 | Pubmed ID: 17509925
One-electron reduction of methanesulfonyl chloride. The fate of MeSO2Cl(.)(-) and MeSO2(.) intermediates in oxygenated solutions and their role in the cis-trans isomerization of mono-unsaturated fatty acids.
Journal of the American Chemical Society Jul, 2007 | Pubmed ID: 17580942
Radical carbonylation with [11C]carbon monoxide promoted by oxygen-centered radicals: experimental and DFT studies of the mechanism.
Journal of the American Chemical Society Jul, 2007 | Pubmed ID: 17608420
Ring opening of the cyclobutane in a thymine dimer radical anion.
Chemistry (Weinheim an der Bergstrasse, Germany) , 2007 | Pubmed ID: 17694531
Trans fatty acids in membranes: the free radical path.
Molecular biotechnology Sep, 2007 | Pubmed ID: 17914159
(5'S)- and (5'R)-5',8-cyclo-2'-deoxyguanosine: mechanistic insights on the 2'-deoxyguanosin-5'-yl radical cyclization.
Chemical research in toxicology Dec, 2007 | Pubmed ID: 17988100
Radical reactions in aqueous medium using (Me3Si)3SiH.
Organic letters Dec, 2007 | Pubmed ID: 17997562
Fatty acid profile of erythrocyte membranes as possible biomarker of longevity.
Rejuvenation research Feb, 2008 | Pubmed ID: 18160025
(Me3Si)3SiH: twenty years after its discovery as a radical-based reducing agent.
Chemistry (Weinheim an der Bergstrasse, Germany) , 2008 | Pubmed ID: 18165952
Solar one-way photoisomerisation of 5',8-cyclo-2'-deoxyadenosine.
Organic & biomolecular chemistry Mar, 2008 | Pubmed ID: 18327334
One-electron reduction of 8-bromo-2-aminoadenosine in the aqueous phase: radiation chemical and DFT studies of the mechanism.
The journal of physical chemistry. B Apr, 2008 | Pubmed ID: 18373377
The reductive desulfurization of Met and Cys residues in bovine RNase A is associated with trans lipids formation in a mimetic model of biological membranes.
Journal of proteome research May, 2008 | Pubmed ID: 18380475
The fate of C5' radicals of purine nucleosides under oxidative conditions.
Journal of the American Chemical Society Jul, 2008 | Pubmed ID: 18528991
Synthesis of all-trans anandamide: a substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation.
Bioorganic & medicinal chemistry Sep, 2008 | Pubmed ID: 18782671
Reaction of hydrated electrons with guanine derivatives: tautomerism of intermediate species.
The journal of physical chemistry. B Feb, 2009 | Pubmed ID: 19161287
A reevaluation of the ambident reactivity of the guanine moiety towards hydroxyl radicals.
Angewandte Chemie (International ed. in English) , 2009 | Pubmed ID: 19226586
Zinc and cadmium complexes of a plant metallothionein under radical stress: desulfurisation reactions associated with the formation of trans-lipids in model membranes.
Chemistry (Weinheim an der Bergstrasse, Germany) Jun, 2009 | Pubmed ID: 19418517
Membrane lipidomics and the geometry of unsaturated fatty acids from biomimetic models to biological consequences.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19763487
Comparison of isoelectronic 8-HO-G and 8-NH2-G derivatives in redox processes.
Journal of the American Chemical Society Nov, 2009 | Pubmed ID: 19821571
Radiation chemical studies of methionine in aqueous solution: understanding the role of molecular oxygen.
Chemical research in toxicology Jan, 2010 | Pubmed ID: 20038187
Radiation-induced formation of purine 5',8-cyclonucleosides in isolated and cellular DNA: high stereospecificity and modulating effect of oxygen.
Organic & biomolecular chemistry Jul, 2010 | Pubmed ID: 20502776
Base-promoted reaction of 5-hydroxyuracil derivatives with peroxyl radicals.
Organic letters Sep, 2010 | Pubmed ID: 20795653
Human serum albumin modifications associated with reductive radical stress.
Molecular bioSystems Mar, 2011 | Pubmed ID: 21161094
Investigation of excess-electron transfer in DNA double-duplex systems allows estimation of absolute excess-electron transfer and CPD cleavage rates.
Chemistry (Weinheim an der Bergstrasse, Germany) Jan, 2011 | Pubmed ID: 21207617
Purine 5',8-cyclonucleoside lesions: chemistry and biology.
Chemical Society reviews Mar, 2011 | Pubmed ID: 21221459
Radical-based alkylation of guanine derivatives in aqueous medium.
Organic & biomolecular chemistry May, 2011 | Pubmed ID: 21431230
Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols.
Organic & biomolecular chemistry May, 2011 | Pubmed ID: 21442126
Radiation-induced reductive modifications of sulfur-containing amino acids within peptides and proteins.
Journal of proteomics Oct, 2011 | Pubmed ID: 21447412
Rat liver mitochondrial membrane characteristics and mitochondrial functions are more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect of different nutritional lipid patterns.
The British journal of nutrition Mar, 2012 | Pubmed ID: 21774841
Lipid markers of "geometrical" radical stress: synthesis of monotrans cholesteryl ester isomers and detection in human plasma.
Journal of the American Chemical Society Sep, 2011 | Pubmed ID: 21851063
Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion.
Diabetes Nov, 2011 | Pubmed ID: 21896929
New insights into the reaction paths of hydroxyl radicals with 2'-deoxyguanosine.
Chemical research in toxicology Dec, 2011 | Pubmed ID: 21939266
Revisiting the reaction of hydroxyl radicals with vicinal diols in water.
Organic & biomolecular chemistry Feb, 2012 | Pubmed ID: 22167177
Recent applications of the (TMS)3SiH radical-based reagent.
Molecules (Basel, Switzerland) , 2012 | Pubmed ID: 22269866
Trans fatty acids: chemical synthesis of eicosapentaenoic acid isomers and detection in rats fed a deodorized fish oil diet.
Chemical research in toxicology Mar, 2012 | Pubmed ID: 22283477
Investigation of reactions postulated to occur during inhibition of ribonucleotide reductases by 2'-azido-2'-deoxynucleotides.
Tetrahedron Jul, 2012 | Pubmed ID: 22711937
Kinetic studies on the formation of sulfonyl radicals and their addition to carbon-carbon multiple bonds.
The journal of physical chemistry. A Jul, 2012 | Pubmed ID: 22724535
Biomimetic models of radical stress and related biomarkers.
Chimia , 2012 | Pubmed ID: 22871276
Role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools.
Expert review of molecular diagnostics Sep, 2012 | Pubmed ID: 23153242
Non-enzymatic modifications in metallothioneins connected to lipid membrane damages: Structural and biomimetic studies under reductive radical stress.
Journal of proteomics Mar, 2013 | Pubmed ID: 23542714
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유