Geert Bultynck

The role of calmodulin for inositol 1,4,5-trisphosphate receptor function.

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor.

Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction.

The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+.

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.

Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells.

The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase.

The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis.

Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.

The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.

Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.

The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells.

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.

Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates.

Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.

Pannexins, distant relatives of the connexin family with specific cellular functions?

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.

Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.

Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.

Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum.

Connexins: sensors and regulators of cell cycling.

STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling.

Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor.

The IP(3) receptor-mitochondria connection in apoptosis and autophagy.

Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction.

Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling.

IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for Aging.

Endoplasmic-reticulum calcium depletion and disease.

A dual role for Ca(2+) in autophagy regulation.

Calcium and connexin-based intercellular communication, a deadly catch?

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability.

Non-channel functions of connexins in cell growth and cell death.

STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function.

Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated.

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway.

The contractile system as a negative regulator of the connexin 43 hemichannel.

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala.

Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy.

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves.

Paracrine signaling through plasma membrane hemichannels.

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system.

Manipulating connexin communication channels: use of peptidomimetics and the translational outputs.

The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor.

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice.

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors.

IP3, a small molecule with a powerful message.

Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions.

Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress.

HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.

mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling.

Curcumin affects proprotein convertase activity: Elucidation of the molecular and subcellular mechanism.

Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels.

Regulation of connexin- and pannexin-based channels by post-translational modifications.

Endothelial calcium dynamics; connexin channels and blood brain barrier function.