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MatTek Corporation

2 ARTICLES PUBLISHED IN JoVE

Biology

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model

Helena Kandárová¹, Patrick Hayden¹, Mitchell Klausner¹, Joseph Kubilus¹, John Sheasgreen¹

In this video, we demonstrate the EpiDerm Skin Irritation test (EpiDerm SIT) developed and validated for in vitro skin irritation testing of chemicals, including cosmetic and pharmaceutical ingredients.

Bioengineering

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Yulia Kaluzhny¹, Helena Kandárová², Laurence d’Argembeau-Thornton¹, Paul Kearney¹, Mitchell Klausner¹

¹MatTek Corporation, ²MatTek In Vitro Life Science Laboratories

We have developed an eye irritation test which utilizes a three dimensional reconstructed human cornea-like epithelial (RhCE) tissue model. The test is able to discriminate between ocular irritant and corrosive materials (GHS Categories 1 and 2 combined) and those that do not require labeling (GHS No Category).