Pfizer, Inc.

1 ARTICLES PUBLISHED IN JoVE

Cancer Research

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Edward Cabral¹, Mary Katherine Montgomery¹, Meaghan Berg², Lisa Kathryn Manzuk², Anand Giddabasappa¹, Ziyue Karen Jiang¹

¹Drug Safety R&D, Discovery & Early Development, Pfizer, Inc., ²Comparative Medicine, Discovery & Early Development, Pfizer, Inc.

This protocol describes the procedure for performing in vivo PET imaging on mice using Body Conforming Animal Molds (BCAMs) in the G8 PET/CT scanner. Technical details on mouse preparation, including proper tumor implantation, optimal positioning, BCAM-assisted PET/CT image acquisition, and data analysis, are provided.