<p class="jove_content">The present protocol describes a method measuring absolute DNA densities within adherent cell nuclei using Voronoi tessellation of single-molecule localization microscopy data, known volume, genome size, and cell cycle stage.</p>

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy

Within the cell nucleus, silent genes are generally located in chromatin areas of high density called heterochromatin, whereas active genes can be mostly ...

Max Planck Institute for Polymer Research

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