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Institute for Chemical and Bioengineering, ETH Zurich

3 ARTICLES PUBLISHED IN JoVE

Bioengineering

Fluorescence detection methods for microfluidic droplet platforms

Xavier Casadevall i Solvas¹, Xize Niu¹, Katherine Leeper¹, Soongwon Cho¹, Soo-Ik Chang², Joshua B. Edel¹, Andrew J. deMello³

¹Department of Chemistry, Imperial College London , ²Department of Biochemistry, Protein Chip Research Center, Chungbuk National University, ³Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich

Droplet-based microfluidic platforms are promising candidates for high throughput experimentation since they are able to generate picoliter, self-compartmentalized vessels inexpensively at kHz rates. Through integration with fast, sensitive and high resolution fluorescence spectroscopic methods, the large amounts of information generated within these systems can be efficiently extracted, harnessed and utilized.

Chemistry

Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment

Afshin Abrishamkar^1,2, Markos Paradinas³, Elena Bailo⁴, Romen Rodriguez-Trujillo⁵, Raphael Pfattner⁵, René M. Rossi¹, Carmen Ocal⁵, Andrew J. deMello², David B. Amabilino⁶, Josep Puigmartí-Luis¹

¹Empa - Swiss Federal Laboratories for Materials Science and Technology, ²Institute of Chemical and Bioengineering, Department of Chemistry and Applied Bioscience, ETH Zurich, ³ICN2-Institut Catala de Nanociencia i Nanotecnologia, ⁴WITec GmbH, ⁵Institut de Ciència de Materials de Barcelona, ⁶School of Chemistry, The University of Nottingham

Herein, we describe the fabrication and operation of a double-layer microfluidic system made of polydimethylsiloxane (PDMS). We demonstrate the potential of this device for trapping, directing the coordination pathway of a crystalline molecular material and controlling chemical reactions onto on-chip trapped structures.

Chemistry

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Afshin Abrishamkar¹, David Rodríguez-San-Miguel², Jorge Andrés Rodríguez Navarro³, Romen Rodriguez-Trujillo⁴, David B. Amabilino⁵, Ruben Mas-Ballesté², Félix Zamora^2,6,7, Andrew J. deMello¹, Josep Puigmarti-Luis¹

¹Institute of Chemical and Bioengineering, Department of Chemistry and Applied Bioscience, ETH Zurich, ²Departamento de Química Inorgánica, Universidad Autónoma de Madrid, ³Departamento de Química Inorgánica, Universidad de Granada, ⁴Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), ⁵School of Chemistry, University of Nottingham, ⁶Condensed Matter Physics Center (IFMAC), Universidad Autónoma de Madrid, ⁷Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia)

We present a novel microfluidic-based method for synthesis of covalent organic frameworks (COFs). We demonstrate how this approach can be used to produce continuous COF fibers, and also 2D or 3D COF structures on surfaces.