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Jikei University School of Medicine

2 ARTICLES PUBLISHED IN JoVE

Medicine

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset (Callithrix jacchus)

Sho Kurihara^*1,2, Masato Fujioka^*3, Tomohiko Yoshida^*1,2, Makoto Koizumi⁴, Kaoru Ogawa³, Hiromi Kojima², Hirotaka James Okano¹

¹Division of Regenerative Medicine, Jikei University School of Medicine, ²Department of Otorhinolaryngology, Jikei University School of Medicine, ³Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, ⁴Laboratory Animal Facilities, Jikei University School of Medicine

We report a surgical method to administrate drugs to the inner ear of a non-human primate, the common marmoset (Callithrix jacchus), via the round window membrane.

Medicine

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Kazuhiko Shirakabe^1,2, Masaaki Higashiyama¹, Naoki Shibuya², Kazuki Horiuchi¹, Masayuki Saruta², Ryota Hokari¹

¹Department of internal medicine, National Defense Medical College, ²Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine

Here, we describe a precise method for collecting thoracic duct lymphocytes and observing the migration of gut-tropic lymphocytes in rat Peyer’s patches for 3 hours using time-lapse photography. This technique can clarify how the dynamics of lymphocytes are affected under inflammatory conditions.