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Shengjing Hospital of China Medical University

4 ARTICLES PUBLISHED IN JoVE

Neuroscience

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Dandan Li^*1,2, Hóngyi Zhào^*2,3, Wei Wei², Nan Liu², Yonghua Dr. Huang²

¹Department of Neurology, Second Hospital of Shanxi Medical University, ²Department of Neurology, PLA Army General Hospital, ³Department of Neurology, NO 261 Hospital of PLA

We present a protocol to induce and detect CMHs caused by LPS injection in Sprague-Dawley rats, which may be utilized in future research investigations on the pathogenesis of CMHs.

JoVE Core

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Shu-Kui Yu^*1, Zheng-De Du^*1, Qing-Ling Song¹, Teng-Fei Qu¹, Yue Qi¹, Wei Xiong¹, Lu He¹, Wei Wei², Shu-Sheng Gong¹, Ke Liu¹

¹Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, ²Department of Otology, Shengjing Hospital of China Medical University

This manuscript describes an experimental protocol for evaluating the morphological characteristics and functional status of ribbon synapses in normal mice. The present model is also suitable for noise-induced and age-related cochlear synaptopathy-restricted models. The correlative results of previous mouse studies are also discussed.

Medicine

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Wei Wei^*1, Hóngyi Zhào^*1,2, Yu Liu², Yonghua Huang¹

¹Department of Neurology, The Seventh Medical Center of PLA Army General Hospital, ²Department of Neurology, NO 984 Hospital of PLA

Here, we present a protocol to show how to perform two types of cognitive assessment tools derived from the paper-pencil version of the Trail Making Test.

Medicine

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Matthew D. Alexander^1,2, Guillaume Hoareau³, Matthew S. Zabriskie¹, Helen Palatinus³, Nitin Ramanujam Chakravarthula³, Chuanzhuo Wang⁴, M. Austin Johnson³

¹Department of Radiology and Imaging Sciences, University of Utah, ²Department of Neurosurgery, University of Utah, ³Department of Emergency Medicine, University of Utah, ⁴Department of Radiology, Shengjing Hospital of China Medical University

Continuous arterial blood pressure recording allows the investigation of impacts of various hemodynamic parameters. This report demonstrates the application of continuous arterial blood pressure monitoring in a large animal model of ischemic stroke for determination of stroke pathophysiology, impact of different hemodynamic factors, and the assessment of novel treatment approaches.