Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal ImmunityJosé Vicente Pérez-Girón 1, Sergio Gómez-Medina 1, Anja Lüdtke 1, Cesar Munoz-Fontela 1
1Laboratory of Emerging Viruses, Heinrich Pette Institute, Leibniz Institute for Experimental Virology
There is an overall lack of knowledge about how vaccines work. Here we propose the combined use of reverse genetics and bone marrow chimeric mice to gain insight into the early host immune responses to vaccines with a special focus on dendritic cells and T cell immunity.
