Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative DiseaseAlba Di Pardo 1, Salvatore Castaldo 1, Luca Capocci 1, Enrico Amico 1, Vittorio Maglione 1
1Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed
In this study, we present an easy and efficient procedure for evaluating the disruption of the blood-brain barrier under neurodegenerative conditions. To achieve our objective, we infused high molecular weight fluorescein isothiocyanate labelled (FITC)-albumin into mouse jugular vein and evaluated its leakage into the brain parenchyma by fluorescence microscopy.
