Xenopus laevis as a Model to Identify Translation ImpairmentAmélie de Broucker 1, Pierre Semaille 1, Katia Cailliau 2, Alain Martoriati 2, Thomas Comptdaer 1, Jean-François Bodart 2, Alain Destée 1, Marie-Christine Chartier-Harlin 1
1Team "Early Stages of Parkinson's Disease" of the Jean-Pierre Aubert Research Center, INSERM UMR-S1172, CHRU Lille, University of Lille 1 and Lille 2, 2Team "Signal Division Regulation", CNRS UMR 8576, University of Lille 1
Protein synthesis control occurs mainly at the translation initiation step, deficiencies in which are linked to diverse disorders. To better understand their etiology, we described here a protocol using Xenopus laevis oocytes assessing the translation of mos transcript in the presence of a mutant of translation initiation factor eIF4G1.
