Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory ResponseMaría Ángeles Higueras 1, Lidia Jiménez-García 1, Sandra Herranz 1, Sonsoles Hortelano *1, Alfonso Luque *1
1Pharmacological Therapies Unit, Research Institute for Rare Diseases, Institute of Health Carlos III
Vascular endothelium tightly controls leukocyte recruitment. Inadequate leukocyte extravasation contributes to human inflammatory diseases. Therefore, searching for novel regulatory elements of endothelial activation is necessary to design improved therapies for inflammatory disorders. Here, we describe a comprehensive methodology to characterize novel endothelial regulators that can modify leukocyte trafficking during inflammation.
