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Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
Nodir Madrahimov 1, Ruslan Natanov 1, Erin C. Boyle 1, Tobias Goecke 1, Ann-Kathrin Knöfel 1, Valentyna Irkha 1, Anna Solovieva 2, Klaus Höffler 1, Ulrich Maus 3, Christian Kühn 1, Issam Ismail 1, Gregor Warnecke 1, Malakh-Lal Shrestha 1, Serghei Cebotari *1, Axel Haverich *1
1Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, 2Department of Hematology, Oncology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, 3Department of Pneumology, Hannover Medical School

This paper describes how to perform cardiopulmonary bypass in mice. This novel model will facilitate the investigation of the molecular mechanisms involved in organ damage.

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Immunology and Infection

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
Vanessa Neuhaus *1, Olga Danov *1, Sebastian Konzok 1, Helena Obernolte 1, Susann Dehmel 1, Peter Braubach 2, Danny Jonigk 2, Hans-Gerd Fieguth 3, Patrick Zardo 4, Gregor Warnecke 4, Christian Martin 5, Armin Braun 1,6, Katherina Sewald 1
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery, Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology, RWTH Aachen University, 6Institute for Immunology, Hannover Medical School

In view of the 3Rs principle, respiratory models as alternatives to animal studies are evolving. Especially for risk assessment of respiratory substances, there is a lack of appropriate assays. Here, we describe the use of human precision-cut lung slices for the assessment of airborne substances.

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Medicine

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
Andreas Voskrebenzev 1,2, Filip Klimeš 1,2, Frank Wacker 1,2, Jens Vogel-Claussen 1,2
1Institute for Diagnostic and Interventional Radiology, Hannover Medical School, 2Member of the German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)

Here, we describe the implementation of phase-resolved functional lung MRI as a contrast-agent-free proton MR technique for the assessment of pulmonary ventilation and perfusion dynamics. Validated and applicable across different field strengths and age groups, it could enhance clinical decision-making in the future by aiding in disease quantification and therapy monitoring.

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