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Medical University of Vienna, Vienna, Austria

2 ARTICLES PUBLISHED IN JoVE

Medicine

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Philipp Königshofer^1,2, Ksenia Brusilovskaya^1,2, Philipp Schwabl^1,2, Bruno K. Podesser³, Michael Trauner¹, Thomas Reiberger^1,2

¹Div. of Gastroenterology and Hepatology, Dept. of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria, ³Center of Biomedical Research, Medical University of Vienna, Vienna, Austria

Here we describe a detailed protocol for invasive measurements of hemodynamic parameters including portal pressure, splanchnic blood flow, and systemic hemodynamics in order to characterize the portal hypertensive syndrome in rats.

Medicine

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Thomas Reiberger^1,2, Philipp Schwabl^1,2, Michael Trauner^1,2, Markus Peck-Radosavljevic^2,3, Mattias Mandorfer^1,2

¹Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, ²Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, ³Department of Internal Medicine and Gastroenterology (IMuG), Klinikum Klagenfurt am Woerthersee

Here, we present a protocol for measurement of hepatic venous pressure gradient (HVPG),the gold standard to diagnose clinically significant portal hypertension. Moreover, we describe how to perform a transjugular liver biopsy within the same session.