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Temerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health

2 ARTICLES PUBLISHED IN JoVE

Medicine

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Katharine Dunlop¹, Pauline Gaprielian⁶, Daniel Blumberger^5,7, Zafiris J. Daskalakis^5,7, Sidney H. Kennedy^2,3,5, Peter Giacobbe^2,3,5, Jonathan Downar^2,3,4,5

¹Institute of Medical Sciences, University of Toronto, ²MRI-Guided rTMS Clinic, University Health Network, ³Department of Psychiatry, University Health Network, ⁴Toronto Western Research Institute, University Health Network, ⁵Department of Psychiatry, University of Toronto, ⁶Faculty of Arts and Science, University of Toronto, ⁷Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health

Here we outline the procedure for MRI-guided repetitive transcranial magnetic stimulation to the dorsomedial prefrontal cortex as an experimental treatment for major depressive disorder.

JoVE Core

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Pantelis Lioumis¹, Reza Zomorrodi¹, Itay Hadas¹, Zafiris J. Daskalakis^1,2, Daniel M. Blumberger^1,2

¹Temerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health, ²Department of Psychiatry and Institute of Medical Science, Faculty of Medicine, University of Toronto

The protocol presented here is for TMS-EEG studies utilizing intracortical excitability test-retest design paradigms. The intent of the protocol is to produce reliable and reproducible cortical excitability measures for assessing neurophysiological functioning related to therapeutic interventions in the treatment of neuropsychiatric diseases such as major depression.