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Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université

2 ARTICLES PUBLISHED IN JoVE

JoVE Core

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Andrea Slezia^*1,5, Christopher M. Proctor^*2,3, Attila Kaszas^1,4, George G. Malliaras^2,3, Adam Williamson^1,5

¹Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), ²Electrical Engineering Division, University of Cambridge, ³Department of Bioelectronics, Centre Microélectronique de Provence - Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), ⁴Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, ⁵Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged

The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus.

Cancer Research

Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma

Marie C. Lefevre¹, Attila Kaszas¹, Gerwin Dijk^1,2, Martin Baca¹, Olivier Baudino², Bastien Marchiori², Loig Kergoat², David Moreau¹, Franck Debarbieux^3,4,5, Rodney P. O'Connor¹

¹Centre CMP, Bioelectronics Department, Mines Saint-Etienne, ²Panaxium SAS, ³Institut Universitaire de France, ⁴Institut des Neurosciences de la Timone (UMR7289), CNRS, Aix-Marseille Université, ⁵Centre Européen de Recherche en Imagerie Médicale, Aix-Marseille Université

This work describes the development of flexible interdigitated electrodes for implementation in 3D brain tumor models, namely, in vitro culture, in ovo model, and in vivo murine model. The proposed method can be used to evaluate the effects of pulsed electric fields on tumors at different levels of complexity.