Inducing Apical Periodontitis in MiceElisheva Goldman 1,2, Eli Reich 1, Itzhak Abramovitz *2, Michael Klutstein *1
1Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University of Jerusalem, 2Department of Endodontics, Hadassah Ein Kerem Medical Center
Here, we present a protocol to locally induce apical periodontitis in mice. We show how to drill a hole in the mouse's tooth and expose its pulp, in order to cause local inflammation. Analysis methods to investigate the nature of this inflammation, such as micro-CT and histology, are also demonstrated.
