Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating PeptideKaridia Konate 1, Quentin Seisel 1, Eric Vivès 1, Prisca Boisguérin 1, Sébastien Deshayes 1
1PHYMEDEXP, INSERM U1046 - CNRS UMR 9214 - University of Montpellier
The fluorescence leakage assay is a simple method that enables the investigation of peptide/membrane interactions in order to understand their involvement in several biological processes and especially the ability of cell-penetrating peptides to disturb phospholipids bilayers during a direct cellular translocation process.
