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The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.

Proteins like integrins and dystroglycan in the cell membranes attach to proteins like laminins and fibronectin in the basal lamina, associating the cell with the extracellular matrix of the connective tissue. The basal lamina present in the kidney, serves as a molecular filter, whereas, at the neuromuscular junction, it surrounds the muscle cells, separating them from the nerve cells at the synapse. The basal lamina further helps regenerate the synapse after an injury and aids in localizing acetylcholine receptors.

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Basal LaminaExtracellular MatrixECMLamina LucidaLamina DensaLamina ReticularisGlycoproteinsCollagenLamininsPerlecanEntactinType IV CollagenIntegrinsDystroglycanMolecular FilterNeuromuscular JunctionSynapseAcetylcholine Receptors

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27.1 : 세포외 기질(Extracellular Matrix)

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27.2 : 글리코사미노글리칸

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27.3 : 콜라겐은 ECM의 주요 구조 단백질입니다.

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27.4 : 피브릴 관련 콜라겐

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27.5 : 엘라스틴은 조직 탄력을 담당합니다.

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27.6 : 피브로넥틴은 ECM과 세포를 연결합니다.

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27.7 : 매트릭스 프로테오글리칸과 당단백질

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27.8 : ECM 분해에서 매트릭스 메탈로프로테아제의 역할

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27.10 : 라미닌은 기저 라미나의 접착 단백질입니다.

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27.11 : 기저 층류의 유형 IV 콜라겐

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