The overall goal of this protocol is to reproduibly and efficiently induce femoral distraction osteogenesis in a rat model to assess functional bone regeneration. This method can help answer key questions in the osteogenesis medicine field about d
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This study describes a reproducible and detailed protocol using a newly developed external fixator for distraction osteogenesis (DO) in a femoral rat model which permits physiological weight-bearing by the animal after removal of the external fixator.