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JoVE Journal

Neuroscience

This content is Free Access.

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

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08:16 min

September 21st, 2021

September 21st, 2021

3,087 Views

0:05

Introduction

1:12

PolyQ Aggregation Assay

3:29

PolyQ-Mediated Neurotoxicity Assays

6:18

Results: Analysis of the Overall Neuroprotective Capacity of Astragalan and its Effect on PolyQ40 Aggregation, Neuronal Death, and Behavioral Dysfunction

7:51

Conclusion

필기록

Here, we present a protocol to assess the neuroprotective activities of test compounds in Caenorhabditis elegans, including polyglutamine aggregation, neuronal death, and chemoavoidance behavior, as well as an exemplary integration of multiple phenotypes.

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