Eugene C. Butcher

Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues.

Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes.

Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy.

The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells.

Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors.

Chemokines and the tissue-specific migration of lymphocytes.

Correlation of tissue distribution, developmental phenotype, and intestinal homing receptor expression of antigen-specific B cells during the murine anti-rotavirus immune response.

Chemokines in rapid leukocyte adhesion triggering and migration.

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines.

Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice.

Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.

Cytokine control of memory B cell homing machinery.

Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers.

Bovine gamma delta T cell subsets express distinct patterns of chemokine responsiveness and adhesion molecules: a mechanism for tissue-specific gamma delta T cell subset accumulation.

Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine.

Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression.

Liver-infiltrating lymphocytes in end-stage hepatitis C virus: subsets, activation status, and chemokine receptor phenotypes.

Rotavirus-specific B cells induced by recent infection in adults and children predominantly express the intestinal homing receptor alpha4beta7.

Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation.

CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1.

A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts.

CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.

Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways.

Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation.

Chemokines in lymphocyte trafficking and intestinal immunity.

Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement.

Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets.

Chemokines in the systemic organization of immunity.

Plasma-cell homing.

RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing.

Method for analyzing signaling networks in complex cellular systems.

Targeting T cell responses by selective chemokine receptor expression.

Murine CD8+ recent thymic emigrants are alphaE integrin-positive and CC chemokine ligand 25 responsive.

An integrative biology approach for analysis of drug action in models of human vascular inflammation.

Unique gene expression program of human germinal center T helper cells.

Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling.

Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models.

CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate.

Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in children.

Systems biology in drug discovery.

Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus.

Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood.

Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver.

Modified representational difference analysis: isolation of differentially expressed mRNAs from rare cell populations.

Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment.

Can cell systems biology rescue drug discovery?

Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling.

Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982.

Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades.

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction.

RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells.

CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium.

Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection.

A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983.

Chemoattractants, extracellular proteases, and the integrated host defense response.

Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands.

T cell chemotaxis in a simple microfluidic device.

Selectin, platelet plays a critical role in granulocyte access to the pregnant mouse uterus under physiological and pathological conditions.

The germinal center response is impaired in the absence of T cell-expressed CXCR5.

DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27.

Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin.

Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation in mice.

Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism.

iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity.

Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs.

Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells.

Lymphocyte electrotaxis in vitro and in vivo.

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.

Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis.

CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease.

An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation.

Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets.

A role for leukocyte-endothelial adhesion mechanisms in epilepsy.

Modeling the role of homologous receptor desensitization in cell gradient sensing.

Chemerin and the recruitment of NK cells to diseased skin.

NMR assignment of human chemerin, a novel chemoattractant.

Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease.

Dynamic T cell migration program provides resident memory within intestinal epithelium.

Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation.

Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation.

Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target.

IL-17 regulates adipogenesis, glucose homeostasis, and obesity.

Panhematin provides a therapeutic benefit in experimental pancreatitis.

Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.

Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins.

A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture.

Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.

Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.

Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis.

Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis.

Expression, Regulation, and Function of Atypical Chemerin Receptor CCRL2 on Endothelial Cells.

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.

The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses.

Chemerin is an antimicrobial agent in human epidermis.

Thymus-homing dendritic cells in central tolerance.

Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses.

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.

Absence of Nkx2-3 homeodomain transcription factor reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.

Leukocyte chemoattractant receptors in human disease pathogenesis.

A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease.

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.

Expression of the mucosal homing receptor alpha4beta7 correlates with the ability of CD8+ memory T cells to clear rotavirus infection.

Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity.

alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus.

Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential.

Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells.

Rules of chemokine receptor association with T cell polarization in vivo.

CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin.

Can cell systems biology rescue drug discovery?

Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells.

Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid.

Leukocyte Trafficking to the Small Intestine and Colon.

Vitamin D immunoregulation through dendritic cells.

Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo.

Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge.

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model.

A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models.

Gut-Selective Integrin-Targeted Therapies for Inflammatory Bowel Disease.

Single-cell analysis of early progenitor cells that build coronary arteries.

Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature.

Collagenase-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry.

DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis.

Papain-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry.

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.

Exploration of Cell Development Pathways through High-Dimensional Single Cell Analysis in Trajectory Space.

Neutrophils Recirculate through Lymph Nodes to Survey Tissues for Pathogens.

A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature.

Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema.

A molecular map of murine lymph node blood vascular endothelium at single cell resolution.

Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification.

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.

A CD22-Shp1 phosphatase axis controls integrin β display and B cell function in mucosal immunity.

Development of follicular dendritic cells in lymph nodes depends on retinoic acid-mediated signaling.

An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression.

Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.

Secreted IgM modulates IL-10 expression in B cells.

Endothelial cell Notch signaling programs cancer-associated fibroblasts to promote tumor immune evasion.

A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS.

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes.