Vessel-sparing Excision and Primary Anastomosis

Podsumowanie

Here, we present an elaborate and efficient protocol to treat isolated short bulbar or posterior urethral strictures with vessel-sparing excision and primary anastomosis.

Streszczenie

Urethroplasty is considered to be the standard treatment for urethral strictures since it provides excellent long-term success rates. For isolated short bulbar or posterior urethral strictures, urethroplasty by excision and primary anastomosis (EPA) is recommended. As EPA only requires the excision of the narrowed segment and the surrounding spongiofibrosis, a full-thickness transection of the corpus spongiosum, as performed in the traditional transecting EPA (tEPA), is usually unnecessary. Jordan et al. introduced the idea of a vessel-sparing approach in 2007, aiming to reduce surgical trauma, especially to the dual arterial blood supply of the urethra, and, thus, potentially reducing the risk of postoperative erectile dysfunction or glans ischemia. This approach could also be beneficial for subsequent urethral interventions such as redo urethroplasty using a free graft, in which a well-vascularized graft bed is imperative. Nevertheless, these potential benefits are only assumptions as prospective studies comparing the functional outcome of both techniques with validated questionnaires are currently lacking. Moreover, vessel-sparing EPA (vsEPA) should at least be able to provide similar surgical outcomes as tEPA. The aim of this paper is to give an elaborate, step-by-step overview of how to manage patients with isolated short bulbar or posterior urethral strictures with vsEPA. The main objective of this manuscript is to outline the surgical technique and to report the representative surgical outcome. A total of 117 patients were managed according to the described protocol. The analysis was performed on the entire patient cohort and on the bulbar (n = 91) and posterior (n = 26) vsEPA group separately. Success rates were 93.4% and 88.5% for the bulbar and posterior vsEPA, respectively. To conclude, vsEPA, as outlined in the protocol, provides excellent success rates with low complication rates for isolated short bulbar and posterior urethral strictures.

Wprowadzenie

Urethroplasty is considered the standard treatment for urethral strictures as it provides excellent long-term success rates^1,2. A numerous amount of surgical techniques has been described, challenging the reconstructive urologist to choose the best approach, considering various stricture modalities such as the number of strictures, the stricture length, the stricture location, the etiology, comorbidities, and previous urethral interventions. For isolated short bulbar urethral strictures, the International Consultation on Urologic Diseases (ICUD) recommends urethroplasty by excision and primary anastomosis (EPA) associated with a composite success rate of 93.8%^3,4.

Urethroplasty by EPA embodies an approach in which the entire diseased segment of the urethra is removed and replaced by healthy adjacent urethra without the need for grafts or flaps to bridge the gap. Traditionally, this approach included the full thickness transection of the corpus spongiosum at the level of the stricture⁵. However, as EPA only requires the excision of the narrowed segment and the surrounding spongiofibrosis, a full thickness transection of the corpus spongiosum, and the dual urethral blood supply within it, is usually unnecessary. Given this background, Jordan et al. introduced the idea of a vessel-sparing approach in 2007, offering a non-transecting alternative to the classic transecting EPA (tEPA)^6,7. This vessel-sparing EPA (vsEPA) has been uprising ever since and several centers have—though slightly modified—implemented this technique in their surgical repertoire^8,9,10,11,12.

The vessel-sparing technique aims to reduce surgical trauma, especially to the dual arterial blood supply of the urethra embedded in the corpus spongiosum. The preservation of the bulbar arteries potentially reduces the risk of postoperative erectile dysfunction or glans ischemia. Furthermore, it could be beneficial for subsequent urethral interventions such as redo urethroplasty using a free graft, in which a well-vascularized graft bed is imperative^8,9. Nevertheless, these potential benefits are only assumptions as prospective studies comparing the functional outcome of both techniques with validated questionnaires are currently lacking.

As important as the functional outcome is, vsEPA should at least be able to provide similar surgical outcomes as tEPA. Promising short-term results have been published and are in line with the success rates reported by the ICUD, but a direct comparison between both techniques has, so far, not been performed^{3,4,8,9,10,11,12}.

Pelvic fracture-related urethral injuries are associated with scar tissue formation and a subsequent urethral stricture or complete obliteration of the membranous urethra. Posterior strictures might also develop after surgery or irradiation to the prostate¹³. For these strictures, urethroplasty with the excision of the scar tissue and bulbo-prostatic anastomosis is recommended as well¹⁴. Traditionally, the bulbar arteries were ligated during this procedure if not already obliterated due to the pelvic fracture. To avoid this, a vessel-sparing variant has been introduced and reported as well^15,16.

The aim of this paper is to give an elaborate, step-by-step overview of how to manage patients with isolated short bulbar or posterior urethral strictures with vsEPA. The main scope is to outline and visualize the surgical technique and to report the representative surgical outcome. An evaluation of the functional outcome parameters is beyond the scope of this paper.

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Protokół

All patients provided a signed written informed consent and the approval of the local Ethics Committee (EC/2014/0438) was obtained.

NOTE: The inclusion criteria for the presented protocol were: male; age ≥18 years; signed written informed consent; fit for operation; isolated urethral stricture; urethral stricture ≤3 cm; urethral stricture only at the bulbar or membranous site. The exclusion criteria were: female; transgender; age <18 years; absence of signed written informed consent; unfit for operation; >1 concomitant urethral strictures; urethral stricture >3 cm; urethral stricture outside of the bulbar or membranous site.

1. Preoperative Work-up

1. Evaluate the patient through history taking, physical examination, and uroflowmetry followed by an ultrasonic residual volume measurement.
2. Confirm the presence of a stricture by urethrography (retrograde and/ or antegrade). If there is any doubt, additionally perform urethroscopy.
3. After the appropriate diagnosis, schedule patients with isolated short bulbar urethral strictures or with strictures at the membranous urethra for urethroplasty by vessel-sparing excision and primary anastomosis (vsEPA). Plan the surgery at least 3 months after any urethral manipulation including catheter use, dilation, or direct vision internal urethrotomy (DVIU). In the case of urinary retention, place a suprapubic catheter to ensure urinary derivation. In the case of pelvic fracture-related urethral injuries, perform urethroplasty at least 3 months after the initial trauma.
4. Perform preoperative investigations to evaluate the patient’s fitness for operation as prescribed by local guidelines. If necessary, conduct therapeutic interventions accordingly.
5. One week before surgery, perform a urine culture with an antibiogram and, in the case of a urinary infection, start the appropriate antibiotics 24 h before surgery. If there is no urinary infection, administer a single shot of 1 g of cefazoline (dissolved in 10 cc of NaCl, 0.9%) intravenously (through the peripheral venous catheter using a 20 cc syringe and an 18 G needle) at the start of the operation.
6. Obtain routine venous thrombo-embolism prophylaxis by the administration of compression stockings.
7. Keep the patients sober at least 6 h before surgery.

2. Initiation of Surgical Procedure

NOTE: The following steps take place after the surgical safety checklist and the administration of general anesthesia.

1. Patient’s positioning
   1. Place the patient on the operating table in a supine position.
   2. Place the patient in a modified lithotomy position in which the knees and the hips are flexed 60–90° with 45° of abduction and the feet and calves are supported in supportive boots or leg holders. Make sure the patient’s buttocks slightly pass the caudal border of the operating table to provide sufficient accessibility. Check extensively for areas with excessive compression to prevent neurovascular compression syndromes.
   3. If necessary, obtain a 10–15° Trendelenburg position to fully visualize the diseased urethra.
2. Start-up of the surgical procedure
   1. Shave and disinfect the exposed perineum and external genitals using an iodine-based scrub as antiseptic.
   2. In the case of the presence of a suprapubic catheter, instill the bladder with 100 mL of diluted (10%) iodine-based scrub.
   3. Create a sterile operating field by the administration of sterile drapes. Keep the operating field as small as possible and include the penis and scrotum without the anus. In the case of the presence of a suprapubic catheter, include this in the operating field to ensure suprapubic access to the urethra, if necessary.
   4. As the surgeon is seated between the legs of the patient, position an assistant next to him/ her and place the instrumentalist on the left side of the patient, handing over the instruments from above the operating field.

3. Surgical Procedure

1. Accessing the bulbar urethra
   1. Make a midline perineal skin incision using a scalpel (blade number 24) and dissect the subcutaneous fat tissue through Colles’ fascia with a monopolar electrocauter (coagulation and cutting mode on 25 Watt and pure) until the bulbospongious muscle is encountered. Coagulate any bleeding vessels with the monopolar electrocauter.
   2. Incise the bulbospongious muscle at the midline using a surgical blade number 24 and dissect it away from the underlying corpus spongiosum with Jones scissors.
   3. Fix the bulbospongious muscle at the perineal skin using 4 silk 2-0 stay sutures and ensure further surgical exposure by a self-retaining retractor: attach the hooks of the elastic stays to the bulbospongious muscle, create sufficient traction, and secure the elastics to one of the slots of the retractor (Figure 1).
   4. Identify the bulbar urethra.
2. Mobilization of the bulbar urethra
   1. Dissect the bulbar urethra circumferentially in a sharp fashion with Jones scissors starting at the mid-bulbar region. Incise Buck’s fascia on each side of the bulbar urethra with Jones scissors allowing a further dorsal dissection of the urethra and a detachment of the dorsal Buck’s fascia from the tunica albuginea of the corpora cavernosa.
   2. Encircle the bulbar urethra with a vessel loop and secure it with a Kocher clamp to facilitate manipulation (Figure 2).
   3. First, continue the dorsal dissection and detachment in the distal direction, towards the penoscrotal angle. Use sharp scissors dissection, closely follow Buck’s fascia in this dorsal detachment as it provides a rather avascular surgical plane. Coagulate the communicating vessels between the corpus spongiosum and the corpora cavernosa with a monopolar electrocauter.
   4. Continue the dorsal dissection proximally, towards the urogenital diaphragm. Do not dissect the bulb of the corpus spongiosum at the anal side and leave the perineal body intact.
3. Opening of the stricture
   1. Introduce a 20Fr silicone urethral catheter or a 20Fr metal sound in the meatus urethrae and pass it up toward the distal extent of the urethral stricture.
   2. At this level, open the urethra dorsally in a longitudinal fashion (dorsal stricturotomy) using a scalpel (blade number 15 or 24).
   3. Place 2 silk 3-0 stay sutures (1 on each side of the opened urethra) to facilitate the exposure of the urethral lumen.
   4. Insert a 3Fr ureteral catheter through the dorsally-opened urethra and pass it up proximally through the strictured area.
   5. Further open the stricture on this 3Fr ureteral catheter using Jones scissors or a surgical blade number 15 until healthy urethral tissue is encountered.
   6. Evaluate the patency and caliber of the proximal urethra by introducing a 20Fr metal sound and move it up toward the bladder.
   7. Place 2 silk 3-0 stay sutures (1 on each side) on the opened proximal urethra.
   8. For bulbar strictures, resect the stricture as well as the surrounding spongiofibrosis using Jones scissors until healthy spongious tissue is encountered ventrally. Leave this healthy spongious tissue intact.
   9. For strictures at the membranous urethra, fully resect the scar tissue using Jones scissors or a surgical blade number 15 until the apex of the prostate is reached. After the removal of the suprapubic catheter, introduce a cystoscope through the suprapubic tract to facilitate the identification of the prostatic apex.
4. Urethral anastomosis
   1. If necessary, split the corpora cavernosa to shorten the distance towards the proximal urethra. Use a surgical blade number 15 on the midline between the corpora cavernosa and once the avascular plane between both corpora is encountered, continue with a blunt dissection.
   2. Grasp the urethral mucosa with a DeBakey forceps with a large grip.
   3. In the case of a bulbar stricture
      1. Create the ventral urethral plate by suturing the ventral ends of the proximal and distal urethra from the inside of the urethral lumen using interrupted 4-0 sutures (polyglactin 910).
      2. Dorsally, spatulate the healthy urethral edges for about 1 cm using Jones scissors and remove the stay sutures.
      3. Close the dorsal edges of the urethral ends transversely over a 20Fr silicone urethral catheter with interrupted 4-0 sutures (polyglactin 910).
      4. Close the corpus spongiosum over the urethra (spongioplasty) using 4-0 sutures (polyglactin 910).
   4. In the case of a stricture or obliteration at the membranous urethra
      1. Spatulate the distal urethral end dorsally and the proximal urethral end ventrally over 1 cm using Jones scissors.
      2. Place eight 4-0 sutures (polyglactin 910) and pass a 20Fr silicone urethral catheter into the bladder.
5. Catheter drain and wound closure
   1. Leave a 20Fr silicone urethral catheter in place.
   2. Leave a 10Fr suction drain behind between the corpus spongiosum and the bulbospongious muscle. Perforate the skin of the right inguinal region with the 10Fr drain needle. Cut the needle off.
   3. Cut the stay sutures with Mayo-Stille scissors, remove the retractor, and close the bulbospongious muscle over the underlying urethra, corpus spongiosum, and suction drain using a 3-0 running suture (polyglactin 910).
   4. Suture Colles’ fascia in a running fashion, also using a 3-0 suture (polyglactin 910). Suture the skin with interrupted Donati stitches using 3-0 sutures (polyglactin 910).
   5. Fix the suction drain at the groin using a silk 2-0 suture and attach the suction drain to the vacuum flask. Apply a perineal compressive dressing.
   6. Flip the penis and transurethral catheter toward the lower abdomen and keep them in place by supporting and compressive underwear.
   7. If a suprapubic catheter was present, remove this, except in the case of previous irradiation.

4. Postoperative Care

1. After recovery, bring the patient to his room and provide standard postoperative care.
2. Remove the suction drain after 24 h.
3. In the case of a preoperatively established urinary infection, continue the antibiotic treatment regimen as prescribed.
4. Disinfect the perineal wound repeatedly and use a hair dryer 3–5x a day to keep the wound dry and neat.
5. In the case of no major complications, discharge the patient from the hospital on postoperative day 2 with the indwelling transurethral catheter in place. Give further instructions, especially regarding wound care, and foresee an appointment to remove the catheter.

5. Follow-up Visits

1. After 7 (simple repair) to 14 days (irradiated cases), perform a voiding cystourethrography (VCUG) and, if there is no or insignificant contrast leakage, remove the transurethral catheter. In the case of significant extravasation, replace the transurethral catheter and perform the VCUG again 1 week later.
2. Schedule follow-up visits 3 months postoperatively, 12 months postoperatively, and annually thereafter. During these visits, evaluate the patient through history taking, a physical examination, uroflowmetry, and an ultrasonic residual volume measurement. Perform further technical investigations such as retrograde urethrography (RUG), VCUG, or urethroscopy only in the case of arguments for stricture recurrence such as symptoms, an obstructive voiding curve, or high residual urinary volumes.
3. Define surgical failure as stricture recurrence requiring additional urethral manipulation, including dilation.

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Wyniki

Between 2011 and 2017, a total of 117 patients with isolated short bulbar (n = 91) or posterior (n = 26) urethral strictures were treated with vsEPA at Ghent University Hospital. The baseline characteristics are displayed in Table 1. The median follow-up was 35 and 45 months for bulbar and posterior strictures, respectively. The strictures were longer in the patients who underwent posterior vsEPA and, accordingly, the number of patients with a calculated...

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Dyskusje

Urethral stricture repair by vessel-sparing excision and primary anastomosis was initially performed at Ghent University Hospital in 2010. Thereafter, it became a standard of practice in the hospital's management of patients with isolated short bulbar or posterior urethral strictures. As the bulb remains attached to the perineal body, access to the posterior urethra and the resection of the fibrotic tissue at that site can be compromised. A distortion of the pubic rami due to a pelvic fracture might further impede ac...

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Materiały

Name	Company	Catalog Number	Comments
iso-Betadine Dermicum 125 mL (1)	Meda Pharma	A-472825
Sterile gown (3)	According to surgeon's preference	NA
Sterile gloves (3 pairs)	According to surgeon's preference	NA
Sterile drapes (4)	Medline	AGBBA073A
Bard-Parker scalpel number 3 (1)	Zepf Medical Instruments	06-1003-00
Bard-Parker scalpel number 4 (1)	KLS Martin Group	10-100-04
Scalpel blade number 15 (1)	Swann-Morton	0205
Scalpel blade number 24 (1)	Swann-Morton	0211
Surgical forceps 14 cm (2)	KLS Martin Group	12-301-14
Monopolar electrocauter Valleylab  (1)	Medtronic	E2100
Electrocauter blade 15 cm (1)	Comepa	CO 150i
Debakey forceps 20 cm (2)	Düfner	06232-20
3-layered compress 30 cm x 45 cm (5)	Mölnlycke Health Care	175260
Surgical compress 10 cm x 10 cm (10)	Hartmann	232088
Mayo-Hegar needle driver 18 cm (1)	Zepf Medical Instruments	24-1804-18
Mayo-Hegar needle driver 25 cm (1)	Zepf Medical Instruments	24-1804-25
Jones scissor 18 cm (1)	Düfner	04940-18
Mayo-Stille scissor 17 cm (1)	Zepf Medical Instruments	08-1700-17
Lone Star retractor (1)	CooperSurgical, Trumbull, CT, USA	72403867
Lone Star elastic stays (4)	CooperSurgical, Trumbull, CT, USA	3311-1G
Vessel loop 45 cm (1)	Braun	1095137
Halsted-Mosquito (6)	KLS Martin Group	13-317-21
20Fr silicone urethral catheter (1)	Yushin Medical Co.	1037B-20
3Fr ureteral catheter (1)	Teleflex	223602
20Fr metal sound (1)	Custom made	NA
Vicryl 4-0 wire (6)	Ethicon	V734D
Vicryl 3-0 wire (2)	Ethicon	VCP316H
Vicryl Rapide 3-0  wire (1)	Ethicon	VF2260
10Fr Drain needle (1)	Vygon	658.10
10Fr Suction drain (1)	Oriplast	203102
Vacuum flask 400 mL (1)	Oriplast	213215AL/QL
Zetuvit 10 cm x 20 cm (1)	Hartmann	413771