Department of Molecular Pathology,
Interdisciplinary Graduate School of Medicine,
Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine
Jianglin Fan is Professor and Chairman of Molecular Pathology at University of Yamanashi School of Medicine, Yamanashi, Japan. He received his MD degree at Yanbian University School of Medicine, China and Ph.D. degree at Saga University, Japan. He got his postdoctoral training at Gladstone Institute, University of California, San Francisco. Dr. Fan has been working on atherosclerosis for more than 30 years and his research interests include elucidation of the molecular mechanisms of atherosclerosis, lipid and lipoprotein metabolism, and inflammation. One of his major achievements was to develop novel transgenic and knockout rabbit models for the study of cardiovascular disease. His work has led to more than 180 publications in prestigious peer-review journals.
Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits.
The American journal of pathology Jan, 2002 | Pubmed ID: 11786416
Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a).
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12196525
A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits.
Journal of atherosclerosis and thrombosis , 2002 | Pubmed ID: 12226556
Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles.
Muscle & nerve Dec, 2002 | Pubmed ID: 12451608
Accelerated atherosclerosis with apolipoprotein(a) and oxidized low-density lipoprotein deposition in acute rejection of transplanted kidney: analogous to atherosclerosis.
Clinical transplantation , 2002 | Pubmed ID: 12464130
Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.
Genes to cells : devoted to molecular & cellular mechanisms Mar, 2003 | Pubmed ID: 12622720
Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit).
Arteriosclerosis, thrombosis, and vascular biology Jul, 2003 | Pubmed ID: 12738683
Inflammatory reactions in the pathogenesis of atherosclerosis.
Journal of atherosclerosis and thrombosis , 2003 | Pubmed ID: 12740479
Transgenic rabbits as therapeutic protein bioreactors and human disease models.
Pharmacology & therapeutics Sep, 2003 | Pubmed ID: 12951161
Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity.
The Journal of biological chemistry Feb, 2004 | Pubmed ID: 14660566
NO-1886 inhibits size of adipocytes, suppresses plasma levels of tumor necrosis factor-alpha and free fatty acids, improves glucose metabolism in high-fat/high-sucrose-fed miniature pigs.
Pharmacological research : the official journal of the Italian Pharmacological Society Mar, 2004 | Pubmed ID: 14726214
Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis.
Laboratory investigation; a journal of technical methods and pathology Jun, 2004 | Pubmed ID: 15122303
A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis.
International journal of experimental pathology Oct, 2004 | Pubmed ID: 15312127
Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit).
Journal of atherosclerosis and thrombosis , 2004 | Pubmed ID: 15356377
Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits.
Transgenic research Jun, 2004 | Pubmed ID: 15359603
Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.
The American journal of pathology Oct, 2004 | Pubmed ID: 15466401
Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis.
Arthritis and rheumatism Oct, 2004 | Pubmed ID: 15476203
High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits.
Metabolism: clinical and experimental Jan, 2005 | Pubmed ID: 15562391
Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase.
Cardiovascular research Feb, 2005 | Pubmed ID: 15639492
Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits.
Atherosclerosis Mar, 2005 | Pubmed ID: 15721013
Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer.
Experimental animals / Japanese Association for Laboratory Animal Science Jul, 2005 | Pubmed ID: 16093649
Localized vessel expression of lipoprotein lipase in rabbits leads to rapid lipid deposition in the balloon-injured arterial wall.
Atherosclerosis Jul, 2006 | Pubmed ID: 16191430
C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance.
The American journal of pathology Oct, 2005 | Pubmed ID: 16192648
Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver: a new model for Kasabach-Merritt syndrome.
Laboratory investigation; a journal of technical methods and pathology Dec, 2005 | Pubmed ID: 16200077
Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits.
Circulation Apr, 2006 | Pubmed ID: 16636188
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2007 | Pubmed ID: 17038632
Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis Aug, 2007 | Pubmed ID: 17045271
Re-establishment of complement C6-deficient rabbit colony by cryopreserved sperm transported from abroad.
Experimental animals / Japanese Association for Laboratory Animal Science Apr, 2007 | Pubmed ID: 17460363
Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions.
Journal of the American Society of Nephrology : JASN Jul, 2007 | Pubmed ID: 17554151
Increased expression of human macrophage metalloelastase (MMP-12) is associated with the invasion of endometrial adenocarcinoma.
Pathology, research and practice , 2007 | Pubmed ID: 17574772
Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet.
Circulation research Feb, 2008 | Pubmed ID: 18032735
Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits.
The American journal of pathology May, 2008 | Pubmed ID: 18403602
The effects of rosiglitazone on aortic atherosclerosis of cholesterol-fed rabbits.
Thrombosis research , 2008 | Pubmed ID: 18561986
Endotoxin accelerates atherosclerosis independent of complement activation.
Thrombosis research Feb, 2009 | Pubmed ID: 18692867
Temporal and quantitative analysis of expression of metalloproteinases (MMPs) and their endogenous inhibitors in atherosclerotic lesions.
Histology and histopathology Dec, 2008 | Pubmed ID: 18830936
Unstable coronary plaques and cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries.
Current opinion in lipidology Dec, 2008 | Pubmed ID: 18957890
Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2009 | Pubmed ID: 19778946
Human C-reactive protein does not promote atherosclerosis in transgenic rabbits.
Circulation Nov, 2009 | Pubmed ID: 19901190
Expression of CXCR4 and its ligand SDF-1 in intestinal-type gastric cancer is associated with lymph node and liver metastasis.
Anticancer research Nov, 2009 | Pubmed ID: 20032431
High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits.
Atherosclerosis Nov, 2010 | Pubmed ID: 20832799
Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII.
Transgenic research Aug, 2011 | Pubmed ID: 21120692
Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome.
Hypertension Apr, 2011 | Pubmed ID: 21357282
Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma).
Aquatic toxicology (Amsterdam, Netherlands) Sep, 2011 | Pubmed ID: 21684243
C-reactive protein is associated with the progression of acute embolic stroke in rabbit model.
Journal of thrombosis and thrombolysis May, 2012 | Pubmed ID: 21874402
Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits.
Journal of atherosclerosis and thrombosis , 2012 | Pubmed ID: 22240910
Expression of TRPV1 in rabbits and consuming hot pepper affects its body weight.
Molecular biology reports Jul, 2012 | Pubmed ID: 22327653
High-dose rosiglitazone is pro-atherogenic in cholesterol-fed rabbits.
Atherosclerosis May, 2012 | Pubmed ID: 22377393
Temporal and quantitative analysis of atherosclerotic lesions in diet-induced hypercholesterolemic rabbits.
Journal of biomedicine & biotechnology , 2012 | Pubmed ID: 22505812
Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo.
Inflammation Aug, 2012 | Pubmed ID: 22527144
Protective effects of 20(s)-protopanaxtriol on viral myocarditis infected by coxsackievirus B3.
Pathobiology : journal of immunopathology, molecular and cellular biology , 2012 | Pubmed ID: 22688124
Characteristics of Himalayan marmots and their response to an atherogenic diet.
Experimental animals / Japanese Association for Laboratory Animal Science , 2012 | Pubmed ID: 22850646
Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits.
Arteriosclerosis, thrombosis, and vascular biology Feb, 2013 | Pubmed ID: 23241412
Expression systems and species used for transgenic animal bioreactors.
BioMed research international , 2013 | Pubmed ID: 23586046
Comparative analyses of lipoprotein lipase, hepatic lipase, and endothelial lipase, and their binding properties with known inhibitors.
PloS one , 2013 | Pubmed ID: 23991054
Probucol and cilostazol exert a combinatorial anti-atherogenic effect in cholesterol-fed rabbits.
Thrombosis research Nov, 2013 | Pubmed ID: 24090606
Probucol inhibits the initiation of atherosclerosis in cholesterol-fed rabbits.
Lipids in health and disease Nov, 2013 | Pubmed ID: 24188322
Effective gene targeting in rabbits using RNA-guided Cas9 nucleases.
Journal of molecular cell biology Feb, 2014 | Pubmed ID: 24403564
Ubiquitin-proteasome-dependent slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication.
Virology Jan, 2014 | Pubmed ID: 24418541
Epidermal growth factor receptor-PI3K signaling controls cofilin activity to facilitate herpes simplex virus 1 entry into neuronal cells.
mBio Jan, 2014 | Pubmed ID: 24425731
Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits.
Journal of atherosclerosis and thrombosis , 2014 | Pubmed ID: 24584175
Urotensin II promotes atherosclerosis in cholesterol-fed rabbits.
PloS one , 2014 | Pubmed ID: 24747943
Effects of cholesterol-loaded cyclodextrins on the rate and the quality of motility in frozen and thawed rabbit sperm.
Experimental animals , 2014 | Pubmed ID: 24770640
Silencing herpes simplex virus type 1 capsid protein encoding genes by siRNA: a promising antiviral therapeutic approach.
PloS one , 2014 | Pubmed ID: 24794394
Effects of type III antifreeze protein on sperm and embryo cryopreservation in rabbit.
Cryobiology Aug, 2014 | Pubmed ID: 24809634
Animal models of C-reactive protein.
Mediators of inflammation , 2014 | Pubmed ID: 24872599
Effects of antisense oligonucleotides against C-reactive protein on the development of atherosclerosis in WHHL rabbits.
Mediators of inflammation , 2014 | Pubmed ID: 24872601
C-reactive protein and arteriosclerosis.
Mediators of inflammation , 2014 | Pubmed ID: 24976688
Demonstration of an add-on effect of probucol and cilostazol on the statin-induced anti-atherogenic effects.
Histology and histopathology Dec, 2014 | Pubmed ID: 25078428
Homocysteine reduces protein S-nitrosylation in endothelium.
International journal of molecular medicine Nov, 2014 | Pubmed ID: 25189662
Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.
Pharmacology & therapeutics Feb, 2015 | Pubmed ID: 25277507
Bisphenol A exposure enhances atherosclerosis in WHHL rabbits.
PloS one , 2014 | Pubmed ID: 25333893
Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits.
Journal of applied toxicology : JAT Sep, 2015 | Pubmed ID: 25619500
Carbonate ion-enriched hot spring water promotes skin wound healing in nude rats.
PloS one , 2015 | Pubmed ID: 25671581
Production of Cloned Miniature Pigs Expressing High Levels of Human Apolipoprotein(a) in Plasma.
PloS one , 2015 | Pubmed ID: 26147378
Motility and fertility of rabbit sperm cryopreserved using soybean lecithin as an alternative to egg yolk.
Theriogenology Oct, 2015 | Pubmed ID: 26208436
Combined use of probucol and cilostazol with atorvastatin attenuates atherosclerosis in moderately hypercholesterolemic rabbits.
Lipids in health and disease Jul, 2015 | Pubmed ID: 26220196
Practical assessment of the quantification of atherosclerotic lesions in apoE⁻/⁻ mice.
Molecular medicine reports Oct, 2015 | Pubmed ID: 26239265
High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Nutrition & metabolism , 2015 | Pubmed ID: 26265929
Production of human apolipoprotein(a) transgenic NIBS miniature pigs by somatic cell nuclear transfer.
Experimental animals , 2016 | Pubmed ID: 26411321
Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits.
BioMed research international , 2015 | Pubmed ID: 26640798
ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.
Atherosclerosis Feb, 2016 | Pubmed ID: 26724529
AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis.
Scientific reports Jan, 2016 | Pubmed ID: 26806558
Dietary Cocoa Powder Improves Hyperlipidemia and Reduces Atherosclerosis in apoE Deficient Mice through the Inhibition of Hepatic Endoplasmic Reticulum Stress.
Mediators of inflammation , 2016 | Pubmed ID: 26980943
Angiotensin II Destabilizes Coronary Plaques in Watanabe Heritable Hyperlipidemic Rabbits.
Arteriosclerosis, thrombosis, and vascular biology 05, 2016 | Pubmed ID: 26988589
Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits.
PloS one , 2016 | Pubmed ID: 26999365
Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models.
Scientific reports 06, 2016 | Pubmed ID: 27245873
Hydrogen sulfide inhibits development of atherosclerosis through up-regulating protein S-nitrosylation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Oct, 2016 | Pubmed ID: 27427853
Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.
PloS one , 2016 | Pubmed ID: 27564380
Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice.
Scientific reports 11, 2016 | Pubmed ID: 27845432
Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction.
Journal of cellular and molecular medicine Feb, 2017 | Pubmed ID: 28244642
Glutathione inhibits antibody and complement-mediated immunologic cell injury via multiple mechanisms.
Redox biology 08, 2017 | Pubmed ID: 28390315
Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits.
Arteriosclerosis, thrombosis, and vascular biology 06, 2017 | Pubmed ID: 28428219
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53.
Stem cells (Dayton, Ohio) 07, 2017 | Pubmed ID: 28436570
Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits.
Arteriosclerosis, thrombosis, and vascular biology 07, 2017 | Pubmed ID: 28546217
Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization.
Arteriosclerosis, thrombosis, and vascular biology 08, 2017 | Pubmed ID: 28642237
Comparative studies of three cholesteryl ester transfer proteins and their interactions with known inhibitors.
PloS one , 2017 | Pubmed ID: 28767652
Principles and Applications of Rabbit Models for Atherosclerosis Research.
Journal of atherosclerosis and thrombosis Mar, 2018 | Pubmed ID: 29046488
Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits.
Mediators of inflammation , 2017 | Pubmed ID: 29317793
Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function.
Cell death & disease 02, 2018 | Pubmed ID: 29415989
Transcriptomic analysis of the liver of cholesterol-fed rabbits reveals altered hepatic lipid metabolism and inflammatory response.
Scientific reports 04, 2018 | Pubmed ID: 29692426
Differential Patterns of Secreted Frizzled-Related Protein 4 (SFRP4) in Adipocyte Differentiation: Adipose Depot Specificity.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2018 | Pubmed ID: 29730658
Corrigendum to "Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits".
Mediators of inflammation , 2018 | Pubmed ID: 29849198
Establishment of a novel non‑alcoholic fatty liver disease model using cholesterol‑fed rabbits with reference to the potential role of endoplasmic reticulum stress.
Molecular medicine reports Sep, 2018 | Pubmed ID: 30015906
Western diet feeding influences gut microbiota profiles in apoE knockout mice.
Lipids in health and disease Jul, 2018 | Pubmed ID: 30021609
Extracellular vesicles derived from donor oviduct fluid improved birth rates after embryo transfer in mice.
Reproduction, fertility, and development Jan, 2019 | Pubmed ID: 30196804
Treatment of atherosclerosis by traditional Chinese medicine: Questions and quandaries.
Atherosclerosis 10, 2018 | Pubmed ID: 30212682
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7.
EBioMedicine Oct, 2018 | Pubmed ID: 30243490
Hypertension Enhances Advanced Atherosclerosis and Induces Cardiac Death in Watanabe Heritable Hyperlipidemic Rabbits.
The American journal of pathology 12, 2018 | Pubmed ID: 30248339
Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2018 | Pubmed ID: 30384378
Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives.
International journal of molecular sciences Nov, 2018 | Pubmed ID: 30413026
Hypoxic and Cold Adaptation Insights from the Himalayan Marmot Genome.
iScience Jan, 2019 | Pubmed ID: 30581096
Detection of potential new biomarkers of atherosclerosis by probe electrospray ionization mass spectrometry.
Metabolomics : Official journal of the Metabolomic Society 02, 2018 | Pubmed ID: 30830369
Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system.
Lipids in health and disease Mar, 2019 | Pubmed ID: 30885208
Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits.
Journal of vascular research , 2019 | Pubmed ID: 30947215
Several circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases.
Lipids in health and disease Apr, 2019 | Pubmed ID: 31010436
Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons.
Chemosphere Aug, 2019 | Pubmed ID: 31102917
Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells.
European journal of pharmacology Oct, 2019 | Pubmed ID: 31310754
Connexin43 Contributes to Inflammasome Activation and Lipopolysaccharide-Initiated Acute Renal Injury Modulation of Intracellular Oxidative Status.
Antioxidants & redox signaling 12, 2019 | Pubmed ID: 31319679
Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis.
Lipids in health and disease Dec, 2019 | Pubmed ID: 31870448
Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits.
Journal of cellular and molecular medicine 04, 2020 | Pubmed ID: 32126159
iMarmot: an integrative platform for comparative and functional genomics of marmots.
BMC genomics Mar, 2020 | Pubmed ID: 32228437
Genetic and molecular features for hepadnavirus and plague infections in the Himalayan marmot.
Genome Jun, 2020 | Pubmed ID: 32308030
Endothelial Lipase Exerts its Anti-Atherogenic Effect through Increased Catabolism of β-VLDLs.
Journal of atherosclerosis and thrombosis May, 2020 | Pubmed ID: 32448826
Apolipoprotein CIII Deficiency Protects Against Atherosclerosis in Knockout Rabbits.
Arteriosclerosis, thrombosis, and vascular biology 09, 2020 | Pubmed ID: 32757647
"Coral Reef"-Like Calcifications: Communities of Uncomplicated Calcified Nodules.
Journal of atherosclerosis and thrombosis Sep, 2020 | Pubmed ID: 32779624
Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits.
Atherosclerosis 01, 2021 | Pubmed ID: 33296791
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