Department of Respiratory Medicine
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6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11773044
Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro.
The Journal of biological chemistry May, 2002 | Pubmed ID: 11880376
Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema.
American journal of respiratory cell and molecular biology Jun, 2002 | Pubmed ID: 12034572
Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy.
The Journal of clinical investigation Dec, 2002 | Pubmed ID: 12464660
Alpha(1)-antitrypsin deficiency, liver disease and emphysema.
The international journal of biochemistry & cell biology Jul, 2003 | Pubmed ID: 12672469
Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12807889
Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema.
American journal of respiratory cell and molecular biology Aug, 2004 | Pubmed ID: 15016619
Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo.
The American journal of pathology Feb, 2005 | Pubmed ID: 15681822
Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z alpha1-antitrypsin.
American journal of respiratory cell and molecular biology Nov, 2006 | Pubmed ID: 16778151
Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.
Chest Jun, 2006 | Pubmed ID: 16778294
Animal models of pulmonary emphysema.
Current drug targets. Inflammation and allergy Dec, 2005 | Pubmed ID: 17305522
Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report.
Journal of medical case reports , 2008 | Pubmed ID: 18681950
Acupuncture induced pneumothorax - a case report.
Acupuncture in medicine : journal of the British Medical Acupuncture Society Sep, 2008 | Pubmed ID: 18818566
Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization.
Journal of cellular and molecular medicine Aug, 2009 | Pubmed ID: 19120695
Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema.
American journal of physiology. Lung cellular and molecular physiology Aug, 2009 | Pubmed ID: 19525388
Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1.
The international journal of biochemistry & cell biology Sep, 2010 | Pubmed ID: 20561599
Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema.
American journal of respiratory cell and molecular biology Aug, 2011 | Pubmed ID: 20971880
Tonsillar cyst: an unusual cause of ventilatory failure.
JRSM short reports , 2010 | Pubmed ID: 21103137
Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration.
Molecular medicine (Cambridge, Mass.) Sep-Oct, 2011 | Pubmed ID: 21494752
Targeting serpins in high-throughput and structure-based drug design.
Methods in enzymology , 2011 | Pubmed ID: 22078534
The serpinopathies studying serpin polymerization in vivo.
Methods in enzymology , 2011 | Pubmed ID: 22078544
Preventing and reversing the cellular consequences of Z alpha-1 antitrypsin accumulation by targeting s4A.
Journal of hepatology Jul, 2012 | Pubmed ID: 22425623
Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2013 | Pubmed ID: 23975926
Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine Apr, 2014 | Pubmed ID: 24592811
Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2014 | Pubmed ID: 24760148
Pneumothorax after endobronchial valve treatment: no drain, no gain?
Respiration; international review of thoracic diseases , 2014 | Pubmed ID: 24903903
Maria E. Laucho-Contreras1,
Katherine L. Taylor1,
Ravi Mahadeva2,
Steve S. Boukedes3,
Caroline A. Owen1,4
1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital - Harvard Medical School,
2Department of Respiratory Medicine, University of Cambridge - Addenbrooke's Hospital,
3Lung Transplant Program, Brigham and Women's Hospital - Harvard Medical School,
4COPD and IPF Programs, Lovelace Respiratory Research Institute
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