Ravi Mahadeva

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro.

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema.

Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy.

Alpha(1)-antitrypsin deficiency, liver disease and emphysema.

Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease.

Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema.

Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo.

Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z alpha1-antitrypsin.

Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.

Animal models of pulmonary emphysema.

Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report.

Acupuncture induced pneumothorax - a case report.

Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization.

Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema.

Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1.

Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema.

Tonsillar cyst: an unusual cause of ventilatory failure.

Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration.

Targeting serpins in high-throughput and structure-based drug design.

The serpinopathies studying serpin polymerization in vivo.

Preventing and reversing the cellular consequences of Z alpha-1 antitrypsin accumulation by targeting s4A.

Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase.

Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease.

Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion.

Pneumothorax after endobronchial valve treatment: no drain, no gain?