Adam G. Schrum

The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering.

Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.

T cell division and death are segregated by mutation of TCRbeta chain constant domains.

Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages.

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes.

High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry.

A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change.

Different T cell receptor signals determine CD8+ memory versus effector development.

Visualization of multiprotein complexes by flow cytometry.

Mechanism of T cell tolerance induced by myeloid-derived suppressor cells.

B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals.

Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.

Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.

Multiplex IP-FCM (immunoprecipitation-flow cytometry): Principles and guidelines for assessing physiologic protein-protein interactions in multiprotein complexes.