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Samuel Lunenfeld Research Institute
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Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
Psychopharmacology Apr, 2005 | Pubmed ID: 15759151
In vivo magnetic resonance imaging and semiautomated image analysis extend the brain phenotype for cdf/cdf mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2006 | Pubmed ID: 16641223
Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Jun, 2006 | Pubmed ID: 16753976
The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Apr, 2007 | Pubmed ID: 16936708
Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2007 | Pubmed ID: 17360389
Behavioral phenotypes of Disc1 missense mutations in mice.
Neuron May, 2007 | Pubmed ID: 17481393
Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.
Psychopharmacology Oct, 2008 | Pubmed ID: 18597079
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.
PLoS biology Feb, 2009 | Pubmed ID: 19243221
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.
Molecular brain , 2009 | Pubmed ID: 19925672
A new model of the disrupted latent inhibition in C57BL/6J mice after bupropion treatment.
Psychopharmacology Feb, 2010 | Pubmed ID: 20013111
Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.
Synapse (New York, N.Y.) Mar, 2011 | Pubmed ID: 20687111
Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.
Neuropharmacology Mar, 2012 | Pubmed ID: 21376063
Parametric and pharmacological modulations of latent inhibition in mouse inbred strains.
Pharmacology, biochemistry, and behavior Dec, 2011 | Pubmed ID: 21903127
Mount Sinai Hospital
Oksana Kaidanovich-Beilin1,
Tatiana Lipina1,
Igor Vukobradovic2,
John Roder1,3,4,5,
James R. Woodgett1,3
1Samuel Lunenfeld Research Institute, Mount Sinai Hospital,
2Toronto Centre for Phenogenomics, Mount Sinai Hospital,
3Department of Medical Biophysics, University of Toronto,
4Department of Psychology, University of Toronto,
5Department of Psychiatry, University of Toronto
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