Wenbiao Chen

A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration.

FlEx-based transgenic reporter lines for visualization of Cre and Flp activity in live zebrafish.

Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish.

PhiC31 integrase induces efficient site-specific excision in zebrafish.

Pineal-specific agouti protein regulates teleost background adaptation.

Generating conditional mutations in zebrafish using gene-trap mutagenesis.

Nutrient excess stimulates β-cell neogenesis in zebrafish.

Conditional control of gene function by an invertible gene trap in zebrafish.

Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish.

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system.

Conditional gene-trap mutagenesis in zebrafish.

Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae.

Spatial regionalization and heterochrony in the formation of adult pallial neural stem cells.

Oncogenic KRAS promotes malignant brain tumors in zebrafish.

Skeletal muscle insulin resistance in zebrafish induces alterations in β-cell number and glucose tolerance in an age- and diet-dependent manner.

Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior.

Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs.

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.

Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation.

A conserved role of αA-crystallin in the development of the zebrafish embryonic lens.

Generation of Targeted Mutations in Zebrafish Using the CRISPR/Cas System.

FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation.

Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish.

Active medulloblastoma enhancers reveal subgroup-specific cellular origins.

Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish.

Zebrafish Genome Engineering Using the CRISPR-Cas9 System.

Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.

Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish.

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.