Wenbiao Chen

Department of Molecular Physiology and Biophysics, Vanderbilt University

Research Area

GeneticsUnit 1

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2018

Other Publications

Article	Year
A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Molecular genetics and genomics : MGG\| PubMed ID: 19221799	2009
FlEx-based transgenic reporter lines for visualization of Cre and Flp activity in live zebrafish. Genesis (New York, N.Y. : 2000)\| PubMed ID: 19415631	2009
Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Molecular cancer\| PubMed ID: 19555497	2009
PhiC31 integrase induces efficient site-specific excision in zebrafish. Transgenic research\| PubMed ID: 20556509	2011
Pineal-specific agouti protein regulates teleost background adaptation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20980662	2010
Generating conditional mutations in zebrafish using gene-trap mutagenesis. Methods in cell biology\| PubMed ID: 21924154	2011
Nutrient excess stimulates β-cell neogenesis in zebrafish. Diabetes\| PubMed ID: 22721970	2012
Conditional control of gene function by an invertible gene trap in zebrafish. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22908272	2012
Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish. Zebrafish\| PubMed ID: 23544990	2013
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23918387	2013
Conditional gene-trap mutagenesis in zebrafish. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24233792	2014
Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 24473439	2014
Spatial regionalization and heterochrony in the formation of adult pallial neural stem cells. Developmental cell\| PubMed ID: 25017692	2014
Oncogenic KRAS promotes malignant brain tumors in zebrafish. Molecular cancer\| PubMed ID: 25644510	2015
Skeletal muscle insulin resistance in zebrafish induces alterations in β-cell number and glucose tolerance in an age- and diet-dependent manner. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 25670827	2015
Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25673850	2015
Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics\| PubMed ID: 25855067	2015
High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research\| PubMed ID: 26048245	2015
Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation. Neuro-oncology\| PubMed ID: 26136493	2016
A conserved role of αA-crystallin in the development of the zebrafish embryonic lens. Experimental eye research\| PubMed ID: 26149094	2015
Generation of Targeted Mutations in Zebrafish Using the CRISPR/Cas System. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26285757	2015
FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes\| PubMed ID: 26420862	2016
Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. The Journal of endocrinology\| PubMed ID: 26446275	2015
Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature\| PubMed ID: 26814967	2016
Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26903647	2016
Zebrafish Genome Engineering Using the CRISPR-Cas9 System. Trends in genetics : TIG\| PubMed ID: 27836208	2016
Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy\| PubMed ID: 27875093	2017
Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish. Frontiers in endocrinology\| PubMed ID: 28184214	2017
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. Cell metabolism\| PubMed ID: 28591638	2017