Adrian Goldman

The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase.

3-Carboxy-cis,cis-muconate lactonizing enzyme from Neurospora crassa: MAD phasing with 80 selenomethionines.

Expression, purification and crystallization of a collagen-binding fragment of Yersinia adhesin YadA.

Structure of Escherichia coli pyruvate formate-lyase with pyruvate.

Structural studies of Yersinia adhesin YadA.

The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia.

The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function.

The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll.

Functional expression and direct visualization of the human alpha 2B -adrenergic receptor and alpha 2B -AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors.

The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation.

Structural studies of metal ions in family II pyrophosphatases: the requirement for a Janus ion.

The first cysteine-rich domain of the receptor GFRalpha1 stabilizes the binding of GDNF.

Unusual twinning in an acetyl coenzyme A synthetase (ADP-forming) from Pyrococcus furiosus.

G protein-coupled receptors show unusual patterns of intrinsic unfolding.

The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture.

Functional studies with membrane-bound and detergent-solubilized alpha2-adrenergic receptors expressed in Sf9 cells.

G-protein-coupled receptor domain overexpression in Halobacterium salinarum: long-range transmembrane interactions in heptahelical membrane proteins.

Intracellularly truncated human alpha2B-adrenoceptors: stable and functional GPCRs for structural studies.

Crystal structure of a glycyl radical enzyme from Archaeoglobus fulgidus.

Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.

Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins: the family II inorganic pyrophosphatase and the serine/threonine phosphatase.

Reindeer beta-lactoglobulin crystal structure with pseudo-body-centred noncrystallographic symmetry.

Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide.

A trimetal site and substrate distortion in a family II inorganic pyrophosphatase.

A complete structural description of the catalytic cycle of yeast pyrophosphatase.

Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.

Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution.

Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion.

Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family.

The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site.

The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.

Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases.

Structure of the actin-depolymerizing factor homology domain in complex with actin.

The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding.

Recent inventions on receptor tyrosine kinase RET modulation.

The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.

The immunoglobulin-binding Eib proteins from Escherichia coli are receptors for IgG Fc.

Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling.

Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering.

Structural determinants of growth factor binding and specificity by VEGF receptor 2.

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.

First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes.

A combined quantum chemical and crystallographic study on the oxidized binuclear center of cytochrome c oxidase.

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein.

The structure of E. coli IgG-binding protein D suggests a general model for bending and binding in trimeric autotransporter adhesins.

Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein.

Crystal structure and role of glycans and dimerization in folding of neuronal leucine-rich repeat protein AMIGO-1.

The translocation domain in trimeric autotransporter adhesins is necessary and sufficient for trimerization and autotransportation.

Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics.

The structure and catalytic cycle of a sodium-pumping pyrophosphatase.

Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases.

Yersinia infection tools-characterization of structure and function of adhesins.

Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi.

Inorganic pyrophosphatases: one substrate, three mechanisms.

The structure of the NTPase that powers DNA packaging into Sulfolobus turreted icosahedral virus 2.

Is the bovine lysosomal phospholipase B-like protein an amidase?

Proton/sodium pumping pyrophosphatases: the last of the primary ion pumps.

The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease.

Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1.

A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters.

A method for detergent-free isolation of membrane proteins in their local lipid environment.

Artificial membranes for membrane protein purification, functionality and structure studies.

Transport mechanism of a glutamate transporter homologue GltPh.

Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism.

The crystal structure of PD1, a Haemophilus surface fibril domain.

Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation.

Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro.

Obesity: Receptors identified for a weight regulator.

Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure.

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi.

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.

Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens.

Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study.

A Simple Strategy to Determine the Dependence of Membrane-Bound Pyrophosphatases on K as a Cofactor.

Defining Dynamics of Membrane-Bound Pyrophosphatases by Experimental and Computational Single-Molecule FRET.

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies.

Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation.

Asymmetry in catalysis by membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor.

Glutamate transporters: a broad review of the most recent archaeal and human structures.

Structure of the UspA1 protein fragment from Moraxella catarrhalis responsible for C3d binding.

Improving on nature's shortcomings: evolving a lipase for increased lipolytic activity, expression and thermostability.

Evolving a lipase for hydrolysis of natural triglycerides along with enhanced tolerance towards a protease and surfactants.