Research Program in Molecular and Integrative Biosciences
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The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase.
Structure (London, England : 1993) Apr, 2002 | Pubmed ID: 11937053
3-Carboxy-cis,cis-muconate lactonizing enzyme from Neurospora crassa: MAD phasing with 80 selenomethionines.
Acta crystallographica. Section D, Biological crystallography May, 2002 | Pubmed ID: 11976482
Expression, purification and crystallization of a collagen-binding fragment of Yersinia adhesin YadA.
Acta crystallographica. Section D, Biological crystallography Jun, 2002 | Pubmed ID: 12037311
Structure of Escherichia coli pyruvate formate-lyase with pyruvate.
Acta crystallographica. Section D, Biological crystallography Dec, 2002 | Pubmed ID: 12454503
Structural studies of Yersinia adhesin YadA.
Advances in experimental medicine and biology , 2003 | Pubmed ID: 12756733
The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia.
Journal of molecular biology Aug, 2003 | Pubmed ID: 12909017
The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function.
Protein science : a publication of the Protein Society Sep, 2003 | Pubmed ID: 12930985
The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll.
The EMBO journal Feb, 2004 | Pubmed ID: 14765110
Functional expression and direct visualization of the human alpha 2B -adrenergic receptor and alpha 2B -AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors.
Protein expression and purification Dec, 2003 | Pubmed ID: 14965773
The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation.
The EMBO journal Apr, 2004 | Pubmed ID: 15044950
Structural studies of metal ions in family II pyrophosphatases: the requirement for a Janus ion.
Biochemistry Nov, 2004 | Pubmed ID: 15533045
The first cysteine-rich domain of the receptor GFRalpha1 stabilizes the binding of GDNF.
The Biochemical journal May, 2005 | Pubmed ID: 15610063
Unusual twinning in an acetyl coenzyme A synthetase (ADP-forming) from Pyrococcus furiosus.
Acta crystallographica. Section D, Biological crystallography Mar, 2005 | Pubmed ID: 15735347
G protein-coupled receptors show unusual patterns of intrinsic unfolding.
Protein engineering, design & selection : PEDS Feb, 2005 | Pubmed ID: 15790574
The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture.
Molecular cell Apr, 2005 | Pubmed ID: 15837420
Functional studies with membrane-bound and detergent-solubilized alpha2-adrenergic receptors expressed in Sf9 cells.
Biochimica et biophysica acta Jun, 2005 | Pubmed ID: 15893292
G-protein-coupled receptor domain overexpression in Halobacterium salinarum: long-range transmembrane interactions in heptahelical membrane proteins.
Proteins Aug, 2005 | Pubmed ID: 15971205
Intracellularly truncated human alpha2B-adrenoceptors: stable and functional GPCRs for structural studies.
Journal of receptor and signal transduction research , 2005 | Pubmed ID: 16149769
Crystal structure of a glycyl radical enzyme from Archaeoglobus fulgidus.
Journal of molecular biology Mar, 2006 | Pubmed ID: 16414072
Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.
The EMBO journal Apr, 2006 | Pubmed ID: 16601698
Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins: the family II inorganic pyrophosphatase and the serine/threonine phosphatase.
Acta crystallographica. Section F, Structural biology and crystallization communications Sep, 2006 | Pubmed ID: 16946472
Reindeer beta-lactoglobulin crystal structure with pseudo-body-centred noncrystallographic symmetry.
Acta crystallographica. Section D, Biological crystallography Nov, 2006 | Pubmed ID: 17057340
Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide.
The FEBS journal Nov, 2006 | Pubmed ID: 17069616
A trimetal site and substrate distortion in a family II inorganic pyrophosphatase.
The Journal of biological chemistry Jan, 2007 | Pubmed ID: 17095506
A complete structural description of the catalytic cycle of yeast pyrophosphatase.
Biochemistry Feb, 2007 | Pubmed ID: 17260952
Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.
Pharmacogenetics and genomics Feb, 2007 | Pubmed ID: 17301691
Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution.
Acta crystallographica. Section D, Biological crystallography Jun, 2007 | Pubmed ID: 17505113
Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion.
The FEBS journal Jun, 2007 | Pubmed ID: 17521332
Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family.
The Journal of biological chemistry Aug, 2007 | Pubmed ID: 17553797
The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site.
Molecular pharmacology Sep, 2007 | Pubmed ID: 17578897
The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.
Drug metabolism and disposition: the biological fate of chemicals Mar, 2008 | Pubmed ID: 18048489
Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases.
Protein engineering, design & selection : PEDS Sep, 2008 | Pubmed ID: 18502788
Structure of the actin-depolymerizing factor homology domain in complex with actin.
The Journal of cell biology Jul, 2008 | Pubmed ID: 18625842
The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding.
The Journal of biological chemistry Dec, 2008 | Pubmed ID: 18845535
Recent inventions on receptor tyrosine kinase RET modulation.
Recent patents on biotechnology , 2008 | Pubmed ID: 19075852
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.
Protein engineering, design & selection : PEDS Apr, 2009 | Pubmed ID: 19258449
The immunoglobulin-binding Eib proteins from Escherichia coli are receptors for IgG Fc.
Molecular immunology May, 2009 | Pubmed ID: 19303642
Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling.
Acta crystallographica. Section F, Structural biology and crystallization communications Jun, 2009 | Pubmed ID: 19478429
Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering.
The Journal of biological chemistry Sep, 2009 | Pubmed ID: 19586912
Structural determinants of growth factor binding and specificity by VEGF receptor 2.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20145116
Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.
Molecular immunology May, 2010 | Pubmed ID: 20378178
First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes.
Infection and immunity Jul, 2010 | Pubmed ID: 20439473
A combined quantum chemical and crystallographic study on the oxidized binuclear center of cytochrome c oxidase.
Biochimica et biophysica acta Jul, 2011 | Pubmed ID: 21211513
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2011 | Pubmed ID: 21285368
Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein.
Acta crystallographica. Section F, Structural biology and crystallization communications May, 2011 | Pubmed ID: 21543876
The structure of E. coli IgG-binding protein D suggests a general model for bending and binding in trimeric autotransporter adhesins.
Structure (London, England : 1993) Jul, 2011 | Pubmed ID: 21742268
Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein.
PloS one , 2011 | Pubmed ID: 21980424
Crystal structure and role of glycans and dimerization in folding of neuronal leucine-rich repeat protein AMIGO-1.
Journal of molecular biology Nov, 2011 | Pubmed ID: 21983541
The translocation domain in trimeric autotransporter adhesins is necessary and sufficient for trimerization and autotransportation.
Journal of bacteriology Feb, 2012 | Pubmed ID: 22155776
Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics.
Drug metabolism and disposition: the biological fate of chemicals Oct, 2012 | Pubmed ID: 22782802
The structure and catalytic cycle of a sodium-pumping pyrophosphatase.
Science (New York, N.Y.) Jul, 2012 | Pubmed ID: 22837527
Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases.
Molecular membrane biology Feb, 2013 | Pubmed ID: 22881431
Yersinia infection tools-characterization of structure and function of adhesins.
Frontiers in cellular and infection microbiology , 2012 | Pubmed ID: 23316485
Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi.
The Journal of biological chemistry Jun, 2013 | Pubmed ID: 23658013
Inorganic pyrophosphatases: one substrate, three mechanisms.
FEBS letters Jun, 2013 | Pubmed ID: 23684653
The structure of the NTPase that powers DNA packaging into Sulfolobus turreted icosahedral virus 2.
Journal of virology Aug, 2013 | Pubmed ID: 23698307
Is the bovine lysosomal phospholipase B-like protein an amidase?
Proteins Feb, 2014 | Pubmed ID: 23934913
Proton/sodium pumping pyrophosphatases: the last of the primary ion pumps.
Current opinion in structural biology Aug, 2014 | Pubmed ID: 24768824
The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease.
The Journal of biological chemistry Apr, 2015 | Pubmed ID: 25659429
Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1.
BMC biochemistry Feb, 2015 | Pubmed ID: 25888394
A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters.
PloS one , 2015 | Pubmed ID: 26606682
A method for detergent-free isolation of membrane proteins in their local lipid environment.
Nature protocols 07, 2016 | Pubmed ID: 27254461
Artificial membranes for membrane protein purification, functionality and structure studies.
Biochemical Society transactions 06, 2016 | Pubmed ID: 27284055
Transport mechanism of a glutamate transporter homologue GltPh.
Biochemical Society transactions 06, 2016 | Pubmed ID: 27284058
Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism.
Nature communications 12, 2016 | Pubmed ID: 27922000
The crystal structure of PD1, a Haemophilus surface fibril domain.
Acta crystallographica. Section F, Structural biology communications 02, 2017 | Pubmed ID: 28177321
Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation.
Structural dynamics (Melville, N.Y.) May, 2017 | Pubmed ID: 28345008
Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro.
PloS one , 2017 | Pubmed ID: 28467503
Obesity: Receptors identified for a weight regulator.
Nature 10, 2017 | Pubmed ID: 28953879
Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure.
Biochimica et biophysica acta Feb, 2018 | Pubmed ID: 28993151
Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi.
PloS one , 2017 | Pubmed ID: 29190743
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.
Proceedings of the National Academy of Sciences of the United States of America 01, 2018 | Pubmed ID: 29247053
Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens.
Research in microbiology Sep - Oct, 2018 | Pubmed ID: 29409983
Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study.
PloS one , 2018 | Pubmed ID: 29889908
A Simple Strategy to Determine the Dependence of Membrane-Bound Pyrophosphatases on K as a Cofactor.
Methods in enzymology , 2018 | Pubmed ID: 30149856
Defining Dynamics of Membrane-Bound Pyrophosphatases by Experimental and Computational Single-Molecule FRET.
Methods in enzymology , 2018 | Pubmed ID: 30149870
Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies.
Biochemical Society transactions 12, 2018 | Pubmed ID: 30514765
Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation.
Journal of molecular biology Apr, 2019 | Pubmed ID: 30878480
Asymmetry in catalysis by membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor.
Science advances May, 2019 | Pubmed ID: 31131322
Glutamate transporters: a broad review of the most recent archaeal and human structures.
Biochemical Society transactions Aug, 2019 | Pubmed ID: 31383819
Structure of the UspA1 protein fragment from Moraxella catarrhalis responsible for C3d binding.
Journal of structural biology Nov, 2019 | Pubmed ID: 31400508
Improving on nature's shortcomings: evolving a lipase for increased lipolytic activity, expression and thermostability.
Protein engineering, design & selection : PEDS 09, 2019 | Pubmed ID: 31403166
Evolving a lipase for hydrolysis of natural triglycerides along with enhanced tolerance towards a protease and surfactants.
Protein engineering, design & selection : PEDS Sep, 2019 | Pubmed ID: 31504920
Keni Vidilaseris*,1,
Niklas G. Johansson*,2,
Ainoleena Turku2,
Alexandros Kiriazis2,
Gustav Boije af Gennäs2,
Jari Yli-Kauhaluoma2,
Henri Xhaard2,
Adrian Goldman1,3
1Research Program in Molecular and Integrative Biosciences, University of Helsinki,
2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki,
3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds