Translational Lung Research Center Heidelberg (TLRC)
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Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman's summary.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 03, 2018 | Pubmed ID: 29229473
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
The European respiratory journal 03, 2018 | Pubmed ID: 29545279
Ion Channel Modulators in Cystic Fibrosis.
Chest 08, 2018 | Pubmed ID: 29750923
Multicentre standardisation of chest MRI as radiation-free outcome measure of lung disease in young children with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 07, 2018 | Pubmed ID: 29805050
Comparison of lung clearance index determined by washout of N and SF in infants and preschool children with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 05, 2019 | Pubmed ID: 30420236
Authors' response: Letter to the Editor 'Comparison of lung clearance index determined by washout of N2 and SF6 in infants and preschool children with cystic fibrosis'.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 05, 2019 | Pubmed ID: 30738803
Normative data for multiple breath washout outcomes in school-aged Caucasian children.
The European respiratory journal 04, 2020 | Pubmed ID: 31862765
New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.
The European respiratory journal 04, 2020 | Pubmed ID: 32139467
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.
Nature communications 04, 2020 | Pubmed ID: 32332792
ENaC inhibition in cystic fibrosis: potential role in the new era of CFTR modulator therapies.
The European respiratory journal 12, 2020 | Pubmed ID: 32732328
IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease.
The European respiratory journal Dec, 2020 | Pubmed ID: 33303549
Effects of Lumacaftor-Ivacaftor on Lung Clearance Index, Magnetic Resonance Imaging and Airway Microbiome in Phe508del Homozygous Patients with Cystic Fibrosis.
Annals of the American Thoracic Society Feb, 2021 | Pubmed ID: 33600745
Chronic rhinosinusitis with nasal polyps is associated with impaired TMEM16A-mediated epithelial chloride secretion.
The Journal of allergy and clinical immunology Feb, 2021 | Pubmed ID: 33609628
A multi-centre, randomized, controlled trial on coaching and telemonitoring in patients with cystic fibrosis: conneCT CF.
BMC pulmonary medicine Apr, 2021 | Pubmed ID: 33882893
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease.
Nature communications Nov, 2021 | Pubmed ID: 34764283
Comparison of the Lung Clearance Index in Preschool Children With Primary Ciliary Dyskinesia and Cystic Fibrosis.
Chest Sep, 2022 | Pubmed ID: 35271842
Cystic fibrosis transmembrane conductance regulator in COPD: a role in respiratory epithelium and beyond.
The European respiratory journal Apr, 2023 | Pubmed ID: 37003609
A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.
The European respiratory journal May, 2023 | Pubmed ID: 37080569
Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis.
The European respiratory journal Aug, 2023 | Pubmed ID: 37414422
The future of cystic fibrosis treatment: from disease mechanisms to novel therapeutic approaches.
Lancet (London, England) Sep, 2023 | Pubmed ID: 37699417
Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases.
Biomaterials science Jul, 2024 | Pubmed ID: 39028033
Cystic fibrosis.
Nature reviews. Disease primers Aug, 2024 | Pubmed ID: 39117676
Neutrophil serine proteases in cystic fibrosis: role in disease pathogenesis and rationale as a therapeutic target.
European respiratory review : an official journal of the European Respiratory Society Jul, 2024 | Pubmed ID: 39293854
How many functioning ciliated airway epithelial cells are necessary for effective mucociliary clearance?
The European respiratory journal Oct, 2024 | Pubmed ID: 39389615
Targeting neutrophil serine proteases in bronchiectasis.
The European respiratory journal Nov, 2024 | Pubmed ID: 39467608
German Center for Lung Research (DZL)
University of Heidelberg
Charité – Universitätsmedizin Berlin
Berlin Institute of Health (BIH)
German Center for Lung Research (DZL), Associated Partner Site, Berlin
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
1Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL),
2Dept. of Translational Pulmonology, University of Heidelberg,
3Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), University of Heidelberg,
4Faculty of Biosciences, Collaboration for Joint Ph.D. Degree between EMBL and Heidelberg University, University of Heidelberg,
5Dept. of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité – Universitätsmedizin Berlin,
6, Berlin Institute of Health (BIH),
7, German Center for Lung Research (DZL), Associated Partner Site, Berlin,
8Dept. of Chemical Physiology and Biochemistry, Oregon Health and Science University
Natascha Drude1,
Kai Diederich2,
Claudia U. Duerr3,
Nadine Haase4,
Christoph Harms5,6,7,8,
Frank Heppner9,10,11,
Marina Jendrach9,10,11,
Pia Kahnau2,
Marina Kolesnichenko12,
Lars Lewejohann2,13,
Claudia Kurreck1,
Anke Lohan14,
Marcus A. Mall15,16,
Dominik Müller4,
Stefan Nagel-Riedasch14,
Bastian Opitz17,
Laura Schaupp15,16,
Gilbert Schönfelder2,18,
Amelie Weber3,
Gerald Willimsky19,20,21,
Yalei Zang1,22,
Stephan P. Rosshart*,23,24,
Andreas Diefenbach*,3,
Stefan Jordan*,3
1BIH QUEST Center for Responsible Research, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin,
2German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R),
3Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
4, Experimental and Clinical Research Center (ECRC) & Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC),
5Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie,
6Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
7, Einstein Center for Neuroscience,
8, German Center for Cardiovascular Research (DZHK), partner site Berlin,
9Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
10, Cluster of Excellence, NeuroCure,
11, German Center for Neurodegenerative Diseases (DZNE) Berlin,
12Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
13Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Freie Universität Berlin,
14Forschungseinrichtungen für Experimentelle Medizin/FEM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
15Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
16, German Center for Lung Research (DZL), associated partner site, Berlin,
17Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
18Division of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health,
19Institute of Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
20, German Cancer Research Center,
21, German Cancer Consortium, partner site Berlin,
22Department of Radiology (including Pediatric Radiology), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
23Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),
24Department of Medicine II, Faculty of Medicine, Medical Center - University of Freiburg
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