Division of Cardiovascular Diseases,
Department of Biochemistry and Molecular Biology,
Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology
Xiaolei Xu has not added Biography.
If you are Xiaolei Xu and would like to personalize this page please email our Author Liaison for assistance.
Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin.
Nature genetics Feb, 2002 | Pubmed ID: 11788825
Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland.
Cell and tissue research Sep, 2002 | Pubmed ID: 12195299
Maternal prolactin composition can permanently affect epidermal gammadeltaT cell function in the offspring.
Developmental and comparative immunology Nov, 2002 | Pubmed ID: 12377224
Opposite effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin on morphology and the expression of prostate specific genes in the normal rat prostate.
The Prostate Jan, 2003 | Pubmed ID: 12481252
Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways.
Biochemistry Jun, 2003 | Pubmed ID: 12809512
Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin.
Molecular genetics and metabolism May, 2006 | Pubmed ID: 16352453
C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jul, 2006 | Pubmed ID: 16754745
Depletion of zebrafish titin reduces cardiac contractility by disrupting the assembly of Z-discs and A-bands.
Circulation research Feb, 2007 | Pubmed ID: 17170364
Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis.
Developmental biology Mar, 2007 | Pubmed ID: 17208216
Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival.
PloS one , 2007 | Pubmed ID: 18000534
Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6.
Circulation research Apr, 2008 | Pubmed ID: 18292601
Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms.
Cardiovascular research Jul, 2008 | Pubmed ID: 18343897
[Effect of higher iron in diet on iron levels and hepcidin mRNA expression levels in rats].
Wei sheng yan jiu = Journal of hygiene research Jul, 2008 | Pubmed ID: 18839536
Distinct functions of Wnt/beta-catenin signaling in KV development and cardiac asymmetry.
Development (Cambridge, England) Jan, 2009 | Pubmed ID: 19103803
Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression.
Developmental dynamics : an official publication of the American Association of Anatomists Jun, 2009 | Pubmed ID: 19322764
Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2.
Developmental biology Jul, 2009 | Pubmed ID: 19427304
Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish.
PloS one , 2009 | Pubmed ID: 19672293
Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly.
Human molecular genetics Nov, 2009 | Pubmed ID: 19679566
[Effect of iron deficiency on vitamin A metabolism in rats].
Wei sheng yan jiu = Journal of hygiene research Sep, 2009 | Pubmed ID: 19877508
Iron-catalyzed, microwave-promoted, one-pot synthesis of 9-substituted xanthenes by a cascade benzylation-cyclization process.
Organic letters Jan, 2010 | Pubmed ID: 19938841
In vivo protein trapping produces a functional expression codex of the vertebrate proteome.
Nature methods Jun, 2011 | Pubmed ID: 21552255
Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish.
Circulation research Sep, 2011 | Pubmed ID: 21757652
Functions of the Wnt/β-catenin pathway in an anemia-induced zebrafish model of cardiomyopathy are location dependent.
Biochemical and biophysical research communications Nov, 2011 | Pubmed ID: 22056559
TOR-autophagy signaling in adult zebrafish models of cardiomyopathy.
Autophagy Jan, 2012 | Pubmed ID: 22186229
Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle.
Development (Cambridge, England) Feb, 2012 | Pubmed ID: 22190638
Quantifying cardiac functions in embryonic and adult zebrafish.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22222517
Target of rapamcyin (TOR)-based therapeutics for cardiomyopathy: Insights from zebrafish genetics.
Cell cycle (Georgetown, Tex.) Feb, 2012 | Pubmed ID: 22262179
Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish.
Circulation. Cardiovascular genetics Apr, 2015 | Pubmed ID: 25583992
Exon- and contraction-dependent functions of titin in sarcomere assembly.
Development (Cambridge, England) Nov, 2016 | Pubmed ID: 27836965
Oxidative Stress-Induced Afterdepolarizations and Protein Kinase C Signaling.
International journal of molecular sciences Mar, 2017 | Pubmed ID: 28358314
Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish.
Scientific reports 04, 2017 | Pubmed ID: 28455512
Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection.
Sensors (Basel, Switzerland) Dec, 2017 | Pubmed ID: 29283402
α-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2012 | Pubmed ID: 22767232
Target of rapamycin (TOR)-based therapy for cardiomyopathy: evidence from zebrafish and human studies.
Trends in cardiovascular medicine Feb, 2012 | Pubmed ID: 22841839
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy Apr, 2012 | Pubmed ID: 22966490
Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening.
Circulation research Feb, 2013 | Pubmed ID: 23283723
New and TALENted genome engineering toolbox.
Circulation research Aug, 2013 | Pubmed ID: 23948583
Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade.
PloS one , 2013 | Pubmed ID: 24312548
Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis.
American journal of physiology. Heart and circulatory physiology Feb, 2014 | Pubmed ID: 24322613
Cardiac troponin T (TNNT2) mutations in chinese dilated cardiomyopathy patients.
BioMed research international , 2014 | Pubmed ID: 25110706
Understanding cardiac sarcomere assembly with zebrafish genetics.
Anatomical record (Hoboken, N.J. : 2007) Sep, 2014 | Pubmed ID: 25125181
Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning.
Biology open , 2015 | Pubmed ID: 26432885
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function.
Scientific reports Mar, 2016 | Pubmed ID: 26935567
De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.
Human genetics Aug, 2016 | Pubmed ID: 27234373
Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: a single-center cohort study.
BMC cardiovascular disorders Jun, 2016 | Pubmed ID: 27296108
A modifier screen identifies as a cardiomyopathy susceptibility gene.
JCI insight Sep, 2016 | Pubmed ID: 27642634
Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model.
Human molecular genetics Jan, 2017 | Pubmed ID: 28007903
Recessive TAF1A mutations reveal ribosomopathy in siblings with end-stage pediatric dilated cardiomyopathy.
Human molecular genetics Aug, 2017 | Pubmed ID: 28472305
Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair.
Scientific reports Aug, 2017 | Pubmed ID: 28819303
Modeling -Associated Dilated Cardiomyopathy in Adult Zebrafish.
Journal of cardiovascular development and disease Mar, 2016 | Pubmed ID: 28955713
Phenotyping cardiomyopathy in adult zebrafish.
Progress in biophysics and molecular biology Oct, 2018 | Pubmed ID: 29884423
A Langendorff-like system to quantify cardiac pump function in adult zebrafish.
Disease models & mechanisms Sep, 2018 | Pubmed ID: 30012855
Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration.
JCI insight Apr, 2019 | Pubmed ID: 30996130
Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy.
Journal of molecular and cellular cardiology Aug, 2019 | Pubmed ID: 31228518
Haploinsufficiency of mechanistic target of rapamycin ameliorates cardiomyopathy in adult zebrafish.
Disease models & mechanisms Oct, 2019 | Pubmed ID: 31492659
Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
Science advances Jan, 2020 | Pubmed ID: 32064346
Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish.
PloS one , 2020 | Pubmed ID: 32401822
A feasibility study for noninvasive measurement of shear wave speed in live zebrafish.
Ultrasonics Sep, 2020 | Pubmed ID: 32417695
Building the vertebrate codex using the gene breaking protein trap library.
eLife 08, 2020 | Pubmed ID: 32779569
Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
Journal of the American Heart Association Sep, 2020 | Pubmed ID: 32808564
Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish.
IEEE sensors journal Jun, 2019 | Pubmed ID: 32855627
Continuous Electrocardiogram Monitoring in Zebrafish with Prolonged Mild Anesthesia.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Jul, 2020 | Pubmed ID: 33018541
Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine.
Frontiers in physiology , 2020 | Pubmed ID: 33329049
Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish Mutants.
Journal of the American Society of Nephrology : JASN Apr, 2021 | Pubmed ID: 33574160
Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration.
Journal of molecular cell biology Apr, 2021 | Pubmed ID: 33582796
TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC Cardiomyopathy.
International journal of molecular sciences May, 2021 | Pubmed ID: 34071043
Deep learning-based framework for cardiac function assessment in embryonic zebrafish from heart beating videos.
Computers in biology and medicine Aug, 2021 | Pubmed ID: 34157469
Disruption of Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure.
BioMed research international , 2021 | Pubmed ID: 34327238
-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity.
Circulation research Oct, 2021 | Pubmed ID: 34384247
A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models.
Bio-protocol Aug, 2021 | Pubmed ID: 34458408
Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2.
Biochimica et biophysica acta. Molecular basis of disease Dec, 2021 | Pubmed ID: 34487812
A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies.
Biosensors & bioelectronics Feb, 2022 | Pubmed ID: 34801796
Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish.
JCI insight Dec, 2021 | Pubmed ID: 34935644
Corrigendum to 'Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration'.
Journal of molecular cell biology Jan, 2022 | Pubmed ID: 35092682
Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network.
Frontiers in cardiovascular medicine , 2022 | Pubmed ID: 35369301
Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy.
Disease models & mechanisms May, 2023 | Pubmed ID: 35481478
A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish.
Genes Jul, 2022 | Pubmed ID: 35893052
Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity.
Oxidative medicine and cellular longevity , 2022 | Pubmed ID: 35965684
A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish.
Hepatology communications Nov, 2022 | Pubmed ID: 36017776
A phenotype-based forward genetic screen identifies as a sick sinus syndrome gene.
eLife Oct, 2022 | Pubmed ID: 36255053
Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality.
eLife Nov, 2022 | Pubmed ID: 36408801
Radiation therapy induces immunosenescence mediated by p90RSK.
Frontiers in cardiovascular medicine , 2022 | Pubmed ID: 36426217
Transcriptome studies of inherited dilated cardiomyopathies.
Mammalian genome : official journal of the International Mammalian Genome Society Jun, 2023 | Pubmed ID: 36749382
Using Zebrafish Animal Model to Study the Genetic Underpinning and Mechanism of Arrhythmogenic Cardiomyopathy.
International journal of molecular sciences Feb, 2023 | Pubmed ID: 36835518
Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play.
Frontiers in cardiovascular medicine , 2023 | Pubmed ID: 36970353
Kidney transcriptome and cystic kidney disease genes in zebrafish.
Frontiers in physiology , 2023 | Pubmed ID: 37256068
Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights.
Frontiers in cardiovascular medicine , 2023 | Pubmed ID: 37781317
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
Cellular and molecular life sciences : CMLS Feb, 2024 | Pubmed ID: 38349408
Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish.
JCI insight Feb, 2024 | Pubmed ID: 38412038
1Department of Biochemistry and Molecular Biology, Mayo Clinic,
2Department of Cardiovascular Medicine, Mayo Clinic,
3Cardiovascular Surgery Department, Guilin Hospital of 2nd Xiangya Hospital, Central South University,
4Cardiovascular Surgery Department, 2nd Xiangya Hospital, Central South University
SOBRE A JoVE
Copyright © 2024 MyJoVE Corporation. Todos os direitos reservados