Xiaolei Xu

Division of Cardiovascular Diseases, Mayo Clinic College of Medicine

Affiliated withMayo Clinic College of Medicine Mayo Clinic Graduate School of Biomedical Sciences Mayo Clinic

Research Area

BiologyMedicineBioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title	2012
Publication title	2018
Publication title	2024
Publication title	2024

Other Publications

Article	Year
Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nature genetics\| PubMed ID: 11788825	2002
Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland. Cell and tissue research\| PubMed ID: 12195299	2002
Maternal prolactin composition can permanently affect epidermal gammadeltaT cell function in the offspring. Developmental and comparative immunology\| PubMed ID: 12377224	2002
Opposite effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin on morphology and the expression of prostate specific genes in the normal rat prostate. The Prostate\| PubMed ID: 12481252	2003
Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways. Biochemistry\| PubMed ID: 12809512	2003
Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin. Molecular genetics and metabolism\| PubMed ID: 16352453	2006
C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16754745	2006
Depletion of zebrafish titin reduces cardiac contractility by disrupting the assembly of Z-discs and A-bands. Circulation research\| PubMed ID: 17170364	2007
Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis. Developmental biology\| PubMed ID: 17208216	2007
Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival. PloS one\| PubMed ID: 18000534	2007
Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6. Circulation research\| PubMed ID: 18292601	2008
Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Cardiovascular research\| PubMed ID: 18343897	2008
[Effect of higher iron in diet on iron levels and hepcidin mRNA expression levels in rats]. Wei sheng yan jiu = Journal of hygiene research\| PubMed ID: 18839536	2008
Distinct functions of Wnt/beta-catenin signaling in KV development and cardiac asymmetry. Development (Cambridge, England)\| PubMed ID: 19103803	2009
Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19322764	2009
Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2. Developmental biology\| PubMed ID: 19427304	2009
Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PloS one\| PubMed ID: 19672293	2009
Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. Human molecular genetics\| PubMed ID: 19679566	2009
[Effect of iron deficiency on vitamin A metabolism in rats]. Wei sheng yan jiu = Journal of hygiene research\| PubMed ID: 19877508	2009
Iron-catalyzed, microwave-promoted, one-pot synthesis of 9-substituted xanthenes by a cascade benzylation-cyclization process. Organic letters\| PubMed ID: 19938841	2010
In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nature methods\| PubMed ID: 21552255	2011
Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish. Circulation research\| PubMed ID: 21757652	2011
Functions of the Wnt/Î²-catenin pathway in an anemia-induced zebrafish model of cardiomyopathy are location dependent. Biochemical and biophysical research communications\| PubMed ID: 22056559	2011
TOR-autophagy signaling in adult zebrafish models of cardiomyopathy. Autophagy\| PubMed ID: 22186229	2012
Wnt/Î²-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development (Cambridge, England)\| PubMed ID: 22190638	2012
Quantifying cardiac functions in embryonic and adult zebrafish. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22222517	2012
Target of rapamcyin (TOR)-based therapeutics for cardiomyopathy: Insights from zebrafish genetics. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22262179	2012
Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish. Circulation. Cardiovascular genetics\| PubMed ID: 25583992	2015
Exon- and contraction-dependent functions of titin in sarcomere assembly. Development (Cambridge, England)\| PubMed ID: 27836965	2016
Oxidative Stress-Induced Afterdepolarizations and Protein Kinase C Signaling. International journal of molecular sciences\| PubMed ID: 28358314	2017
Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish. Scientific reports\| PubMed ID: 28455512	2017
Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection. Sensors (Basel, Switzerland)\| PubMed ID: 29283402	2017
α-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22767232	2012
Target of rapamycin (TOR)-based therapy for cardiomyopathy: evidence from zebrafish and human studies. Trends in cardiovascular medicine\| PubMed ID: 22841839	2012
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening. Circulation research\| PubMed ID: 23283723	2013
New and TALENted genome engineering toolbox. Circulation research\| PubMed ID: 23948583	2013
Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade. PloS one\| PubMed ID: 24312548	2013
Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 24322613	2014
Cardiac troponin T (TNNT2) mutations in chinese dilated cardiomyopathy patients. BioMed research international\| PubMed ID: 25110706	2014
Understanding cardiac sarcomere assembly with zebrafish genetics. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 25125181	2014
Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biology open\| PubMed ID: 26432885	2015
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Scientific reports\| PubMed ID: 26935567	2016
De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy. Human genetics\| PubMed ID: 27234373	2016
Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: a single-center cohort study. BMC cardiovascular disorders\| PubMed ID: 27296108	2016
A modifier screen identifies as a cardiomyopathy susceptibility gene. JCI insight\| PubMed ID: 27642634	2016
Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model. Human molecular genetics\| PubMed ID: 28007903	2017
Recessive TAF1A mutations reveal ribosomopathy in siblings with end-stage pediatric dilated cardiomyopathy. Human molecular genetics\| PubMed ID: 28472305	2017
Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Scientific reports\| PubMed ID: 28819303	2017
Modeling -Associated Dilated Cardiomyopathy in Adult Zebrafish. Journal of cardiovascular development and disease\| PubMed ID: 28955713	2016
Phenotyping cardiomyopathy in adult zebrafish. Progress in biophysics and molecular biology\| PubMed ID: 29884423	2018
A Langendorff-like system to quantify cardiac pump function in adult zebrafish. Disease models & mechanisms\| PubMed ID: 30012855	2018
Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration. JCI insight\| PubMed ID: 30996130	2019
Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy. Journal of molecular and cellular cardiology\| PubMed ID: 31228518	2019
Haploinsufficiency of mechanistic target of rapamycin ameliorates cardiomyopathy in adult zebrafish. Disease models & mechanisms\| PubMed ID: 31492659	2019
Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Science advances\| PubMed ID: 32064346	2020
Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish. PloS one\| PubMed ID: 32401822	2020
A feasibility study for noninvasive measurement of shear wave speed in live zebrafish. Ultrasonics\| PubMed ID: 32417695	2020
Building the vertebrate codex using the gene breaking protein trap library. eLife\| PubMed ID: 32779569	2020
Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. Journal of the American Heart Association\| PubMed ID: 32808564	2020
Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish. IEEE sensors journal\| PubMed ID: 32855627	2019
Continuous Electrocardiogram Monitoring in Zebrafish with Prolonged Mild Anesthesia. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference\| PubMed ID: 33018541	2020
Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine. Frontiers in physiology\| PubMed ID: 33329049	2020
Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish Mutants. Journal of the American Society of Nephrology : JASN\| PubMed ID: 33574160	2021
Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology\| PubMed ID: 33582796	2021
TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC Cardiomyopathy. International journal of molecular sciences\| PubMed ID: 34071043	2021
Deep learning-based framework for cardiac function assessment in embryonic zebrafish from heart beating videos. Computers in biology and medicine\| PubMed ID: 34157469	2021
Disruption of Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure. BioMed research international\| PubMed ID: 34327238	2021
-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity. Circulation research\| PubMed ID: 34384247	2021
A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models. Bio-protocol\| PubMed ID: 34458408	2021
Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 34487812	2021
A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies. Biosensors & bioelectronics\| PubMed ID: 34801796	2022
Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight\| PubMed ID: 34935644	2021
Corrigendum to 'Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration'. Journal of molecular cell biology\| PubMed ID: 35092682	2022
Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network. Frontiers in cardiovascular medicine\| PubMed ID: 35369301	2022
Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy. Disease models & mechanisms\| PubMed ID: 35481478	2023
A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Genes\| PubMed ID: 35893052	2022
Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity. Oxidative medicine and cellular longevity\| PubMed ID: 35965684	2022
A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications\| PubMed ID: 36017776	2022
A phenotype-based forward genetic screen identifies as a sick sinus syndrome gene. eLife\| PubMed ID: 36255053	2022
Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality. eLife\| PubMed ID: 36408801	2022
Radiation therapy induces immunosenescence mediated by p90RSK. Frontiers in cardiovascular medicine\| PubMed ID: 36426217	2022
Transcriptome studies of inherited dilated cardiomyopathies. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 36749382	2023
Using Zebrafish Animal Model to Study the Genetic Underpinning and Mechanism of Arrhythmogenic Cardiomyopathy. International journal of molecular sciences\| PubMed ID: 36835518	2023
Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play. Frontiers in cardiovascular medicine\| PubMed ID: 36970353	2023
Kidney transcriptome and cystic kidney disease genes in zebrafish. Frontiers in physiology\| PubMed ID: 37256068	2023
Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights. Frontiers in cardiovascular medicine\| PubMed ID: 37781317	2023
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling. Cellular and molecular life sciences : CMLS\| PubMed ID: 38349408	2024
Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish. JCI insight\| PubMed ID: 38412038	2024