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Center for Tropical and Emerging Global Diseases
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Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.
International journal of antimicrobial agents Jun, 2007 | Pubmed ID: 17395432
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.
Nature medicine May, 2008 | Pubmed ID: 18425131
CD8+ T cells in Trypanosoma cruzi infection.
Current opinion in immunology Aug, 2009 | Pubmed ID: 19646853
In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds.
PLoS neglected tropical diseases Jul, 2010 | Pubmed ID: 20644616
Oral exposure to Trypanosoma cruzi elicits a systemic CD8⁺ T cell response and protection against heterotopic challenge.
Infection and immunity Aug, 2011 | Pubmed ID: 21628516
Methodological advances in drug discovery for Chagas disease.
Expert opinion on drug discovery Jun, 2011 | Pubmed ID: 21712965
Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA.
Expert opinion on drug discovery 09, 2011 | Pubmed ID: 22646217
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice.
The Journal of infectious diseases Jan, 2014 | Pubmed ID: 23945371
Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence.
Molecular microbiology Nov, 2013 | Pubmed ID: 24033456
Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells.
Infection and immunity 09, 2016 | Pubmed ID: 27354447
Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins.
mBio 11, 2017 | Pubmed ID: 29114029
Trypanosoma cruzi 13C-labeled O-Glycan standards for mass spectrometry.
Glycobiology 04, 2019 | Pubmed ID: 30649355
Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases.
International journal for parasitology. Drugs and drug resistance 12, 2020 | Pubmed ID: 32829099
A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease.
Science translational medicine 10, 2020 | Pubmed ID: 33115952
Identification of Growth Inhibitors with Activity In Vivo within a Collection of Licensed Drugs.
Microorganisms Feb, 2021 | Pubmed ID: 33669310
University of Georgia
Fernando Sanchez-Valdez1,
Ángel M. Padilla1,
Juan M. Bustamante1,
Caleb W. D. Hawkins1,
Rick L. Tarleton1,2
1Center for Tropical and Emerging Global Diseases, University of Georgia,
2Department of Cellular Biology, University of Georgia
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