Center for Tropical and Emerging Global Diseases,
Department of Cellular Biology
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Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.
Infection and immunity Nov, 1998 | Pubmed ID: 9784506
Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection.
Infection and immunity Oct, 2002 | Pubmed ID: 12228281
Cutting edge: dysfunctional CD8+ T cells reside in nonlymphoid tissues during chronic Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2003 | Pubmed ID: 12594245
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR.
Molecular and biochemical parasitology Jun, 2003 | Pubmed ID: 12798506
Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection.
Vaccine Jun, 2003 | Pubmed ID: 12798651
Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruzi.
Molecular and biochemical parasitology Sep, 2003 | Pubmed ID: 12967712
Chagas disease: a role for autoimmunity?
Trends in parasitology Oct, 2003 | Pubmed ID: 14519582
TcruziDB: an integrated Trypanosoma cruzi genome resource.
Nucleic acids research Jan, 2004 | Pubmed ID: 14681430
Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice.
Infection and immunity Jul, 2004 | Pubmed ID: 15213153
Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2005 | Pubmed ID: 15661921
A Heuristic method for assigning a false-discovery rate for protein identifications from Mascot database search results.
Molecular & cellular proteomics : MCP Jun, 2005 | Pubmed ID: 15703444
New approaches in vaccine development for parasitic infections.
Cellular microbiology Oct, 2005 | Pubmed ID: 16153238
CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes.
PLoS pathogens Aug, 2006 | Pubmed ID: 16879036
A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi.
Genome biology , 2007 | Pubmed ID: 17567905
Immune system recognition of Trypanosoma cruzi.
Current opinion in immunology Aug, 2007 | Pubmed ID: 17651955
TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection.
European journal of immunology Oct, 2007 | Pubmed ID: 17823982
The challenges of Chagas Disease-- grim outlook or glimmer of hope.
PLoS medicine Dec, 2007 | Pubmed ID: 18162039
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.
Nature medicine May, 2008 | Pubmed ID: 18425131
Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2008 | Pubmed ID: 18684955
High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection.
PLoS neglected tropical diseases , 2008 | Pubmed ID: 18841200
HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.
PLoS neglected tropical diseases , 2008 | Pubmed ID: 18846233
Eliminating Chagas disease: challenges and a roadmap.
BMJ (Clinical research ed.) Apr, 2009 | Pubmed ID: 19366739
Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi.
BMC microbiology May, 2009 | Pubmed ID: 19432966
Chromosome level assembly of the hybrid Trypanosoma cruzi genome.
BMC genomics , 2009 | Pubmed ID: 19486522
Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2009 | Pubmed ID: 19553540
CD8+ T cells in Trypanosoma cruzi infection.
Current opinion in immunology Aug, 2009 | Pubmed ID: 19646853
The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi.
BMC genomics , 2009 | Pubmed ID: 19664227
Chronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2009 | Pubmed ID: 19692645
Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Dec, 2009 | Pubmed ID: 19877967
Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina.
Microbes and infection May, 2010 | Pubmed ID: 20123034
Generation of Trypanosoma cruzi-specific CD8+ T-cell immunity is unaffected by the absence of type I interferon signaling.
Infection and immunity Jul, 2010 | Pubmed ID: 20457790
CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2010 | Pubmed ID: 20530265
In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds.
PLoS neglected tropical diseases Jul, 2010 | Pubmed ID: 20644616
Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization.
BMC genomics , 2011 | Pubmed ID: 21385342
Oral exposure to Trypanosoma cruzi elicits a systemic CD8⁺ T cell response and protection against heterotopic challenge.
Infection and immunity Aug, 2011 | Pubmed ID: 21628516
Methodological advances in drug discovery for Chagas disease.
Expert opinion on drug discovery Jun, 2011 | Pubmed ID: 21712965
Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.
PLoS neglected tropical diseases Dec, 2011 | Pubmed ID: 22180798
Transgenic parasites accelerate drug discovery.
Trends in parasitology Mar, 2012 | Pubmed ID: 22277131
Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease.
PloS one , 2012 | Pubmed ID: 22574131
Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA.
Expert opinion on drug discovery 09, 2011 | Pubmed ID: 22646217
Is Chagas disease really the "new HIV/AIDS of the Americas"?
PLoS neglected tropical diseases , 2012 | Pubmed ID: 23145193
A systematic review of high quality diagnostic tests for Chagas disease.
PLoS neglected tropical diseases , 2012 | Pubmed ID: 23145201
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice.
The Journal of infectious diseases Jan, 2014 | Pubmed ID: 23945371
Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence.
Molecular microbiology Nov, 2013 | Pubmed ID: 24033456
Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen.
Nature communications , 2013 | Pubmed ID: 24149620
Frequency of IFNγ-producing T cells correlates with seroreactivity and activated T cells during canine Trypanosoma cruzi infection.
Veterinary research Jan, 2014 | Pubmed ID: 24456537
The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells.
Cell host & microbe Oct, 2014 | Pubmed ID: 25299330
Chagas disease and the london declaration on neglected tropical diseases.
PLoS neglected tropical diseases Oct, 2014 | Pubmed ID: 25299701
CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi.
mBio Dec, 2014 | Pubmed ID: 25550322
Chemokine receptor 7 (CCR7)-expression and IFNγ production define vaccine-specific canine T-cell subsets.
Veterinary immunology and immunopathology Apr, 2015 | Pubmed ID: 25758065
CD8+ T cells in Trypanosoma cruzi infection.
Seminars in immunopathology May, 2015 | Pubmed ID: 25921214
A framework for ontology-based question answering with application to parasite immunology.
Journal of biomedical semantics , 2015 | Pubmed ID: 26185615
Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells.
Infection and immunity 09, 2016 | Pubmed ID: 27354447
Chagas Disease: A Solvable Problem, Ignored.
Trends in molecular medicine Oct, 2016 | Pubmed ID: 27523778
Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi.
BMC genomics 09, 2016 | Pubmed ID: 27619017
The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to in Serodiscordant Subjects.
Frontiers in immunology , 2017 | Pubmed ID: 28966620
Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins.
mBio 11, 2017 | Pubmed ID: 29114029
Spontaneous dormancy protects during extended drug exposure.
eLife 03, 2018 | Pubmed ID: 29578409
Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection.
PLoS pathogens 11, 2018 | Pubmed ID: 30419010
Drug Discovery for Kinetoplastid Diseases: Future Directions.
ACS infectious diseases 02, 2019 | Pubmed ID: 30543391
Protozoan persister-like cells and drug treatment failure.
Nature reviews. Microbiology 10, 2019 | Pubmed ID: 31444481
Chagas Disease Drug Discovery: Multiparametric Lead Optimization against in Acylaminobenzothiazole Series.
Journal of medicinal chemistry 11, 2019 | Pubmed ID: 31657555
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.
Antimicrobial agents and chemotherapy 08, 2020 | Pubmed ID: 32571827
Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion.
Journal of immunology (Baltimore, Md. : 1950) 08, 2020 | Pubmed ID: 32591392
A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease.
Science translational medicine 10, 2020 | Pubmed ID: 33115952
Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease.
PLoS pathogens 01, 2021 | Pubmed ID: 33508020
A flexible, pan-species, multi-antigen platform for the detection and monitoring of SARS-CoV-2-specific antibody responses.
medRxiv : the preprint server for health sciences Jan, 2021 | Pubmed ID: 33532799
Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease.
The Journal of antimicrobial chemotherapy 05, 2021 | Pubmed ID: 33693664
High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA.
PLoS neglected tropical diseases 03, 2021 | Pubmed ID: 33788859
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