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Leeds Institute of Cardiovascular and Metabolic Medicine
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Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Diabetes Sep, 2012 | Pubmed ID: 22733797
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.
Diabetes Jun, 2013 | Pubmed ID: 23349484
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.
Atherosclerosis Sep, 2013 | Pubmed ID: 23958265
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
Stem cells (Dayton, Ohio) Oct, 2014 | Pubmed ID: 24916783
Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.
Arteriosclerosis, thrombosis, and vascular biology Sep, 2014 | Pubmed ID: 25012136
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.
Circulation research Mar, 2017 | Pubmed ID: 27920123
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.
Diabetes Nov, 2017 | Pubmed ID: 28830894
Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries.
Diabetes & vascular disease research Mar, 2019 | Pubmed ID: 30295509
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage.
American journal of physiology. Cell physiology Jul, 2020 | Pubmed ID: 32401607
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
The Journal of clinical investigation Aug, 2020 | Pubmed ID: 32407295
Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity.
EMBO reports May, 2021 | Pubmed ID: 33934497
Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat.
Circulation research Sep, 2021 | Pubmed ID: 34420367
University of Leeds
Oliver I. Brown1,
Katherine I. Bridge1,
Sam Straw1,
Natallia Makava1,
Jason Scragg1,
Sunti Limumpornpetch1,
Cheukyau Luk1,
Jessica Smith1,
Anna Skromna1,
Alexander F. Bruns1,
Piruthivi Sukumar1,
Lee D. Roberts1,
Richard Cubbon1,
Klaus K. Witte1,
Stephen Wheatcroft1,
Mark T. Kearney1
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds
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