Mark T. Kearney

Somatostatin receptor subtype expression in the human heart: differential expression by myocytes and fibroblasts.

IGF-binding protein-2 protects against the development of obesity and insulin resistance.

Inter-subject differences in constitutive expression levels of the clock gene in man.

Insulin resistance and endothelial cell dysfunction: studies in mammalian models.

Aspirin and mortality in patients with diabetes sustaining acute coronary syndrome.

Role of IGF-1 in glucose regulation and cardiovascular disease.

Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event.

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis.

Vascular insulin-like growth factor-I resistance and diet-induced obesity.

Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse.

Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.

Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.

The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease.

Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration.

Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.

Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras.

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.

Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus.

Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis.

Sympathetic activation and vasoregulation in response to carbohydrate ingestion in patients with congestive heart failure.

Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology.

Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.

Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm.

Importance of insulin resistance to vascular repair and regeneration.

Changing the way we think about endothelial cell insulin sensitivity, nitric oxide, and the pathophysiology of type 2 diabetes: the FoxO is loose.

Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction.

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.

Response to Comment on: Sukumar et al. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes 2013;62:2130-2134.

Pacing-associated left ventricular dysfunction? Think reprogramming first!

Calcium, phosphate and calcium phosphate product are markers of outcome in patients with chronic heart failure.

Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.

Patients with long-term permanent pacemakers have a high prevalence of left ventricular dysfunction.

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.

The microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: a cardiovascular magnetic resonance study.

Piezo1 integration of vascular architecture with physiological force.

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Chronic heart failure and type 2 diabetes mellitus: The last battle?

Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.

An evaluation of 20 year survival in patients with diabetes mellitus and acute myocardial infarction.

Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure.

Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance.

Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification.

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis.

Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.

Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure.

A Novel and Practical Screening Tool for the Detection of Silent Myocardial Infarction in Patients With Type 2 Diabetes.

Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction.

Lung Function Abnormalities in Smokers with Ischemic Heart Disease.

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain.

Diabetes mellitus and heart failure: a deadly duo.

Response by Viswambharan and Kearney to Letter Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop".

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.

Diabetes Mellitus, Microalbuminuria, and Subclinical Cardiac Disease: Identification and Monitoring of Individuals at Risk of Heart Failure.

Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes.

Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance.

Rate-Response Programming Tailored to the Force-Frequency Relationship Improves Exercise Tolerance in Chronic Heart Failure.

Devices in heart failure; diagnosis, detection and disease modification.

Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure.

Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes.

Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin.

Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice.

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure.

Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries.

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity.

Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction.

Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction.

Prospective evaluation and long-term follow-up of patients referred to secondary care based upon natriuretic peptide levels in primary care.

Prognostic Significance of Incidental Nonsustained Ventricular Tachycardia Detected on Pacemaker Interrogation.

TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice.

Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease.

Heart failure: A preventable and treatable complication of type 2 diabetes.

Optimising pacemaker therapy and medical therapy in pacemaker patients for heart failure: protocol for the OPT-PACE randomised controlled trial.

Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.

Piezo1 channel activation mimics high glucose as a stimulator of insulin release.

Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction.

Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology.

Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca Handling After Pressure Overload.

Inorganic Nitrate Promotes Glucose Uptake and Oxidative Catabolism in White Adipose Tissue Through the XOR-Catalyzed Nitric Oxide Pathway.

IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice.

Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study.

Infection-Related Hospitalization in Heart Failure With Reduced Ejection Fraction: A Prospective Observational Cohort Study.

Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage.

Prioritizing symptom management in the treatment of chronic heart failure.

Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy.

Effect of disease-modifying agents and their association with mortality in multi-morbid patients with heart failure with reduced ejection fraction.

Association of heart failure and its comorbidities with loss of life expectancy.

Response by Gierula et al to Letter Regarding Article, "Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study".

Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data.

Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study.

Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study.

Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity.

Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis.

Impact of QRS duration on left ventricular remodelling and survival in patients with heart failure.

Suboptimal Dosing of β-Blockers in Chronic Heart Failure: A Missed Opportunity?

Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat.

Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling.

Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction.

Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study.

Personalised reprogramming to prevent progressive pacemaker-related left ventricular dysfunction: A phase II randomised, controlled clinical trial.

Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity.

Diabetes mellitus and the causes of hospitalisation in people with heart failure.

Systemic Inflammation Is Associated With Future Risk of Fatal Infection: An Observational Cohort Study.

Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess.

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators.

Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity.

Guideline-directed medical therapy is similarly effective in heart failure with mildly reduced ejection fraction.

Atrial fibrillation and risk of progressive heart failure in patients with preserved ejection fraction heart failure.

Reduction of heart failure guideline-directed medication during hospitalization: prevalence, risk factors, and outcomes.

Efficacy of interval exercise training to improve vascular health in sedentary postmenopausal females.

Correction: Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data.

Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.

Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial.

Atrial secondary mitral regurgitation: prevalence, characteristics, management, and long-term outcomes.

Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study.

Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Aortic Stenosis.