Brian K. Kennedy

Mammalian transcription factors in yeast: strangers in a familiar land.

LMNA mutations in atypical Werner's syndrome.

Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.

Sir2-independent life span extension by calorie restriction in yeast.

Large-scale identification in yeast of conserved ageing genes.

Substrate-specific activation of sirtuins by resveratrol.

A-type nuclear lamins, progerias and other degenerative disorders.

Genes determining yeast replicative life span in a long-lived genetic background.

LMNA mutations in progeroid syndromes.

Nuclear tumor suppressors in space and time.

HIV protease inhibitors block adipocyte differentiation independently of lamin A/C.

The enigmatic role of Sir2 in aging.

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.

Increased life span due to calorie restriction in respiratory-deficient yeast.

Extension of chronological life span in yeast by decreased TOR pathway signaling.

Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation.

Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".

Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest.

Sirtuins in aging and age-related disease.

Aging: progeria and the lamin connection.

Lifespan extension in Caenorhabditis elegans by complete removal of food.

Genome-wide identification of conserved longevity genes in yeast and worms.

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function.

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

Recent developments in yeast aging.

Does resveratrol activate yeast Sir2 in vivo?

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.

Protein translation, 2007.

Single-gene deletions that restore mating competence to diploid yeast.

A method for high-throughput quantitative analysis of yeast chronological life span.

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.

Protein translation, 2008.

Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53.

Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.

A-type nuclear lamins act as transcriptional repressors when targeted to promoters.

A molecular mechanism of chronological aging in yeast.

Histone H4 lysine 16 acetylation regulates cellular lifespan.

The TOR pathway comes of age.

Ageing: A midlife longevity drug?

Hot topics in aging research: protein translation, 2009.

Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.

Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Translate this ... during dietary restriction.

Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice.

Progeria syndromes and ageing: what is the connection?

Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.

Old yeast can't handle the noise.

TOR on the brain.

TOR and ageing: a complex pathway for a complex process.

Hot topics in aging research: protein translation and TOR signaling, 2010.

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.

Asymmetric segregation: the shape of things to come?

A genomic analysis of chronological longevity factors in budding yeast.

Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.

Trinations aging symposium.

Aged worms erase epigenetic history.

Sir2 deletion prevents lifespan extension in 32 long-lived mutants.

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.

Genome-wide analysis of yeast aging.

The Buck Institute: An inside look.

A new chronological survival assay in mammalian cell culture.