Department of Molecular & Integrative Physiology
Dr. Xue’s lab is focused on studying molecular mechanisms for inflammatory bowel disease (IBD) and colorectal cancer (CRC). He utilizes cell line and enteroid cultures, mouse models, patient tissues and a wide array of molecular and biochemical methodologies. Several ongoing projects in the lab include:
Why are micronutrients essential for cancer cell growth?
How does mitochondrial metabolism regulate the progress of cancer?
Whether stress activated pathways play a role in cancer cell metabolism?
What role does hypoxia signaling have in intestinal inflammation and colorectal cancer?
What is the critical link between nutrient homeostasis, inflammation and cancer?
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis.
Cancer research May, 2012 | Pubmed ID: 22419665
Two chiral coordination polymers: preparation and X-ray structures of mono(4-sulfo-L-phenylalanine)(diaqua) zinc(II) and copper(II) complexes.
Inorganic chemistry Jun, 2002 | Pubmed ID: 12055012
A cluster rearrangement of an open cubane (Cu4Br4) to a prismane (Cu6Br6) in a copper(I)-olefin network.
Angewandte Chemie (International ed. in English) Aug, 2002 | Pubmed ID: 12203419
Novel, acentric metal-organic coordination polymers from hydrothermal reactions involving in situ ligand synthesis.
Angewandte Chemie (International ed. in English) Oct, 2002 | Pubmed ID: 12386852
Hydrothermal preparation of novel Cd(II) coordination polymers employing 5-(4-pyridyl)tetrazolate as a bridging ligand.
Inorganic chemistry Dec, 2002 | Pubmed ID: 12470047
Differential gene expression in primary and recurrent carotid stenosis.
Biochemical and biophysical research communications Mar, 2003 | Pubmed ID: 12615063
Altered expression of vascular endothelial growth factor and its receptors in normal saphenous vein and in arterialized and stenotic vein grafts.
American journal of surgery Nov, 2003 | Pubmed ID: 14599626
[Effects of sowing times on the spike differentiation of different wheat varieties under the climate of warm winter].
Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban Oct, 2003 | Pubmed ID: 14986353
Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis.
Liver international : official journal of the International Association for the Study of the Liver May, 2007 | Pubmed ID: 17403198
Role of mitochondrial permeability transition in human renal tubular epithelial cell death induced by aristolochic acid.
Toxicology and applied pharmacology Jul, 2007 | Pubmed ID: 17521691
Thermal cyclodehydrogenations to form 6-membered rings: cyclizations of [5]helicenes.
Organic letters Sep, 2007 | Pubmed ID: 17760450
Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock.
Biochemical pharmacology Feb, 2008 | Pubmed ID: 18191816
Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Oct, 2008 | Pubmed ID: 18495746
Roles of reactive oxygen species and MAP kinases in the primary rat hepatocytes death induced by toosendanin.
Toxicology Jul, 2008 | Pubmed ID: 18499325
Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice.
Journal of ethnopharmacology Sep, 2008 | Pubmed ID: 18582552
The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury.
Toxicology letters Apr, 2009 | Pubmed ID: 19429231
[Changes in the mRNA expressions of myocardial cytoskeletal proteins in endotoxemic rats].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University Jun, 2009 | Pubmed ID: 19726336
beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism.
Acta pharmacologica Sinica Nov, 2009 | Pubmed ID: 19890363
[Role of Na(+)-K(+)-ATPase in lipopolysaccharide-induced cardiomyocyte hypertrophy in rats].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University Sep, 2010 | Pubmed ID: 20855249
Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.
Toxicological sciences : an official journal of the Society of Toxicology Dec, 2010 | Pubmed ID: 20855424
[Progress of the study of mechanism on drug induced kidney injury].
Yao xue xue bao = Acta pharmaceutica Sinica Oct, 2010 | Pubmed ID: 21348296
Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis.
The Journal of biological chemistry Jun, 2011 | Pubmed ID: 21498508
Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.
Hepatology (Baltimore, Md.) Aug, 2011 | Pubmed ID: 21538443
[Determination of tracer gas contents in sediment pore water of gas hydrate area by two-dimensional gas chromatography].
Se pu = Chinese journal of chromatography / Zhongguo hua xue hui Jan, 2011 | Pubmed ID: 21574403
Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.
Toxicology letters Aug, 2011 | Pubmed ID: 21596114
Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology Aug, 2011 | Pubmed ID: 21613233
Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I.
Molecular pharmaceutics Dec, 2011 | Pubmed ID: 21980933
Structural basis and kinetics of force-induced conformational changes of an αA domain-containing integrin.
PloS one , 2011 | Pubmed ID: 22140490
Targeting of dicer-2 and RNA by a viral RNA silencing suppressor in Drosophila cells.
Journal of virology May, 2012 | Pubmed ID: 22438534
[Effects of somatostatin in a rabbit model of abdominal compartment syndrome induced by prolonged intra-abdominal hypertension].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University Mar, 2012 | Pubmed ID: 22445990
The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.
Molecular and cellular biology Oct, 2012 | Pubmed ID: 22869521
[Effects of abdominal compartment syndrome on circulation and respiratory function in rabbits].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University Sep, 2012 | Pubmed ID: 22985571
Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.
Carcinogenesis Jan, 2013 | Pubmed ID: 23042097
[Analysis of death characteristics and its potential mechanisms in rats with endotoxin- induced cardiomyopathy].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Dec, 2012 | Pubmed ID: 23168204
High Frequency of Putative Ovarian Cancer Stem Cells With CD44/CK19 Coexpression Is Associated With Decreased Progression-Free Intervals In Patients With Recurrent Epithelial Ovarian Cancer.
Reproductive sciences (Thousand Oaks, Calif.) May, 2013 | Pubmed ID: 23171677
Evaluation of risk factors for venous thromboembolism in Chinese women with epithelial ovarian cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Jan, 2013 | Pubmed ID: 23196757
Membrane association of Wuhan nodavirus protein A is required for its ability to accumulate genomic RNA1 template.
Virology May, 2013 | Pubmed ID: 23490047
Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca(2+) leak by reducing oxidative modification of ryanodine receptors.
Free radical biology & medicine Jul, 2013 | Pubmed ID: 23499836
The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth.
Toxicology and applied pharmacology 07, 2019 | Pubmed ID: 31054940
The Role of Immune Cells and Cytokines in Intestinal Wound Healing.
International journal of molecular sciences Dec, 2019 | Pubmed ID: 31816903
Death from Covid-19 of 23 Health Care Workers in China.
The New England journal of medicine 06, 2020 | Pubmed ID: 32294342
Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19.
Aging Apr, 2020 | Pubmed ID: 32320384
Exposure time determines the protective effect of Trichinella spiralis on experimental colitis.
Microbial pathogenesis May, 2020 | Pubmed ID: 32442663
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