Robert V. Intine

Polymerase chain reaction-mediated mutagenesis in sequences resistant to homogeneous amplification.

La protein and its associated small nuclear and nucleolar precursor RNAs.

Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs.

BCR/ABL activates mdm2 mRNA translation via the La antigen.

Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.

CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism.

Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.

Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.

Human La is found at RNA polymerase III-transcribed genes in vivo.

The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells.

Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation.

Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation.

Mouse and human La proteins differ in kinase substrate activity and activation mechanism for tRNA processing.

De novo formation of a subnuclear body.

Limb regeneration is impaired in an adult zebrafish model of diabetes mellitus.

Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression.

Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms.

Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish.