Institute of Pharmacology
Area of expertise: Cardiac Cellular Electrophysiology and Calcium Handling, Arrhythmias
Niels Voigt is professor of molecular pharmacology at the Institute of Pharmacology at the Georg-August University Göttingen. He graduated and received his MD from the University of Dresden in 2007. He worked as a postdoctoral scientist at the Institute of Pharmacology in Dresden, at the Medical Faculty Mannheim, Heidelberg University and at the Institute of Pharmacology at the Duisburg-Essen University. In 2013, he obtained the specialization in Pharmacology and Toxicology. His field of interest is the regulation of ion channels and calcium signaling in the normal and diseased heart. He has received numerous research awards e.g. the Oskar-Lapp-Research Award (2015) from the German Cardiac Society and the Best of Basic Science Abstracts Award from the American Heart Association (2013).
DNA-programmed control of photosensitized singlet oxygen production.
Journal of the American Chemical Society Apr, 2006 | Pubmed ID: 16568974
Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation.
Cardiovascular research Jun, 2007 | Pubmed ID: 17362895
Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes.
Cardiovascular research Jan, 2008 | Pubmed ID: 18006448
Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation.
Naunyn-Schmiedeberg's archives of pharmacology Mar, 2010 | Pubmed ID: 19760273
Single-molecule chemical reactions on DNA origami.
Nature nanotechnology Mar, 2010 | Pubmed ID: 20190747
Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation.
Circulation. Arrhythmia and electrophysiology Oct, 2010 | Pubmed ID: 20657029
Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.
Circulation. Arrhythmia and electrophysiology Oct, 2010 | Pubmed ID: 20660541
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.
Cardiovascular research Mar, 2011 | Pubmed ID: 20943673
Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart.
Methods in enzymology , 2010 | Pubmed ID: 21036255
Functional patterning of DNA origami by parallel enzymatic modification.
Bioconjugate chemistry Apr, 2011 | Pubmed ID: 21413714
A DNA tile actuator with eleven discrete states.
Angewandte Chemie (International ed. in English) Apr, 2011 | Pubmed ID: 21425422
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Circulation May, 2011 | Pubmed ID: 21555709
DNA origami: a quantum leap for self-assembly of complex structures.
Chemical Society reviews Dec, 2011 | Pubmed ID: 21594298
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
The Journal of clinical investigation Aug, 2011 | Pubmed ID: 21785215
Recent advances in the molecular pathophysiology of atrial fibrillation.
The Journal of clinical investigation Aug, 2011 | Pubmed ID: 21804195
Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation.
Circulation Sep, 2011 | Pubmed ID: 21859974
Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling.
Circulation research Oct, 2011 | Pubmed ID: 21903936
Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation.
Circulation research Oct, 2011 | Pubmed ID: 21921263
DNA-programmed Glaser-Eglinton reactions for the synthesis of conjugated molecular wires.
Angewandte Chemie (International ed. in English) Nov, 2011 | Pubmed ID: 21948766
Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice.
Circulation research Feb, 2012 | Pubmed ID: 22158709
Multilayer DNA origami packed on hexagonal and hybrid lattices.
Journal of the American Chemical Society Jan, 2012 | Pubmed ID: 22187940
Proarrhythmic atrial calcium cycling in the diseased heart.
Advances in experimental medicine and biology , 2012 | Pubmed ID: 22453988
Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.
Circulation May, 2012 | Pubmed ID: 22456474
Role of RyR2 phosphorylation at S2814 during heart failure progression.
Circulation research May, 2012 | Pubmed ID: 22511749
Calcium handling and atrial fibrillation.
Wiener medizinische Wochenschrift (1946) Jul, 2012 | Pubmed ID: 22695810
Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation.
Circulation Oct, 2012 | Pubmed ID: 22992321
Cellular and molecular correlates of ectopic activity in patients with atrial fibrillation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Nov, 2012 | Pubmed ID: 23104921
The biology of human pulmonary veins: does it help us to better understand AF pathophysiology in patients?
Heart rhythm : the official journal of the Heart Rhythm Society Mar, 2013 | Pubmed ID: 23237913
New directions in antiarrhythmic drug therapy for atrial fibrillation.
Future cardiology Jan, 2013 | Pubmed ID: 23259476
MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation.
Circulation Apr, 2013 | Pubmed ID: 23459615
Impaired Na(+)-dependent regulation of acetylcholine-activated inward-rectifier K(+) current modulates action potential rate dependence in patients with chronic atrial fibrillation.
Journal of molecular and cellular cardiology Mar, 2013 | Pubmed ID: 23531443
Finding Ms or Mr Right: Which miRNA to target in AF?
Journal of molecular and cellular cardiology 01, 2017 | Pubmed ID: 27866930
Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.
Circulation Feb, 2017 | Pubmed ID: 27927712
Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy.
European heart journal Jun, 2017 | Pubmed ID: 28057773
Stretch-activated two-pore-domain (K) potassium channels in the heart: Focus on atrial fibrillation and heart failure.
Progress in biophysics and molecular biology 11, 2017 | Pubmed ID: 28526353
The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.
British journal of pharmacology 08, 2017 | Pubmed ID: 28542844
In search for novel functions of adenosine 5'-triphosphate (ATP) in the heart.
Cardiovascular research 12, 2017 | Pubmed ID: 29186438
Report on the Ion Channel Symposium : Organized by the German Cardiac Society Working Group on Cellular Electrophysiology (AG 18).
Herzschrittmachertherapie & Elektrophysiologie Mar, 2018 | Pubmed ID: 29313139
Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K) channels in murine disease models: focus on TASK-1.
Basic research in cardiology 06, 2018 | Pubmed ID: 29881975
German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management.
Clinical research in cardiology : official journal of the German Cardiac Society Jun, 2019 | Pubmed ID: 30306295
Axial Tubule Junctions Activate Atrial Ca Release Across Species.
Frontiers in physiology , 2018 | Pubmed ID: 30349482
ESC Congress 2018 highlights in basic science: a report from the Scientists of Tomorrow.
Cardiovascular research 11, 2018 | Pubmed ID: 30351376
Ryanodine receptor dysfunction and the resolution revolution: how Nobel Prize-winning techniques transform cardiovascular research.
Cardiovascular research 12, 2018 | Pubmed ID: 30476015
N-glycosylation-dependent regulation of hK17.1 currents.
Molecular biology of the cell 06, 2019 | Pubmed ID: 30969900
Scientists on the Spot: Autophagy and heart disease.
Cardiovascular research 08, 2019 | Pubmed ID: 31263872
CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect.
The Journal of physiology May, 2020 | Pubmed ID: 32394454
Altered Atrial Cytosolic Calcium Handling Contributes to the Development of Postoperative Atrial Fibrillation.
Cardiovascular research Jun, 2020 | Pubmed ID: 32520995
Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Jul, 2020 | Pubmed ID: 32572487
Insights into cardiovascular research in Göttingen and Heidelberg: a report by the ESC Scientists of Tomorrow.
Cardiovascular research Oct, 2020 | Pubmed ID: 32754726
Cellular and mitochondrial mechanisms of atrial fibrillation.
Basic research in cardiology Nov, 2020 | Pubmed ID: 33258071
1Institute of Pharmacology and Toxicology, University Medical Center Goettingen, Goettingen, Germany,
2DZHK (German Center for Cardiovascular Research), Partner Site Goettingen, Germany,
3, Cairn Research Ltd, Faversham, United Kingdom,
4Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Goettingen, Germany
Philipp Tomsits*,1,2,3,
Dominik Schüttler*,1,2,3,
Stefan Kääb1,2,
Sebastian Clauss*,1,2,3,
Niels Voigt*,4,5,6
1Department of Medicine I, University Hospital Munich, Campus Großhadern, Ludwig-Maximilians University Munich (LMU),
2Partner Site Munich, Munich Heart Alliance (MHA), DZHK (German Centre for Cardiovascular Research),
3Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians University Munich (LMU),
4Institute of Pharmacology and Toxicology, University Medical Center Göttingen,
5Partner Site Göttingen, DZHK (German Centre for Cardiovascular Research),
6Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen
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