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Missouri State University

2 ARTICLES PUBLISHED IN JoVE

Chemistry

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Matthew A. Ellis¹, Giovanna Grandinetti², Katye M. Fichter¹

¹Department of Chemistry, Missouri State University, ²Center for Molecular Microscopy, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research

In this protocol, the synthesis of Cd-free InP/ZnS quantum dots (QDs) is detailed. InP-based QDs are gaining popularity due to the toxicity of Cd²⁺ ions that may be released through nanoparticle degradation. After synthesis, QDs are solubilized in water using an amphiphilic polymer for use in biomedical applications.

Labeling Neuronal Morphology Using Custom Diolistic Techniques

Lyon Hough¹, Michael E. Brown²

¹Department of Biomedical Sciences, Missouri State University, ²Department of Pathology, Saint Louis University School of Medicine

Here, we present a protocol for custom diolistic labeling. The customization of this fluorescent neuronal labeling method provides a modifiable technique that can be adapted to a wide variety of research goals and applications in the analysis of neuronal morphology.