Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in RatsQimiao Hu *1, Xiaoli Zheng *1, Ruixiang Chen 1, Boyu Liu 1, Yan Tai 2, Xiaomei Shao 1, Jianqiao Fang 1, Boyi Liu 1
1Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, 2Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University
Provided here is a protocol that details steps to establish an animal model of chronic post-ischemia pain (CPIP). This is a well-recognized model mimicking human complex regional pain syndrome type-I. Mechanical and thermal hypersensitivities are further evaluated, as well as capsaicin-induced nocifensive behaviors observed in the CPIP rat model.
